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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	10,438,287	10,442,467
BlackRock, Inc.	[2025-06-30]	SOLE	6,588,914	6,808,698
Deep Track Capital LP	[2025-06-30]	SOLE	6,064,910	6,064,910
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,351,652
Commodore Capital LP	[2025-06-30]	SOLE	3,948,653	3,948,653
Baker Bros Advisors LP	[2025-06-30]	SOLE	3,882,125	3,882,125
Redmile Group LLC	[2025-06-30]	SOLE	3,732,888	3,732,888
Point72 Asset Management LP	[2025-06-30]	DFND	0	3,703,594
State Street Corp	[2025-06-30]	DFND	2,410,049	2,532,154
Soleus Capital Management LP	[2025-06-30]	SOLE	2,422,833	2,422,833
Morgan Stanley	[2025-06-30]	DFND	1,984,316	2,167,121
Vestal Point Capital LP	[2025-06-30]	SOLE	2,000,000	2,000,000
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,852,684	1,998,634
Geode Capital Management LLC	[2025-06-30]	DFND	1,881,960	1,881,960
Citadel Advisors LLC	[2025-06-30]	DFND	1,640,335	1,640,335
UBS Group AG	[2025-06-30]	DFND	1,589,040	1,589,040
ARK Investment Management LLC	[2025-06-30]	SOLE	1,575,032	1,575,032
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,465,053
Sumitomo Mitsui Trust Group, Inc.	[2025-06-30]	DFND	1,391,638	1,391,638
Nikko Asset Management Americas Inc	[2025-06-30]	SOLE	1,148,977	1,389,274
Kynam Capital Management LP	[2025-06-30]	SOLE	1,173,605	1,173,605
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,096,985	1,096,985
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	967,620	967,620
Millennium Management LLC	[2025-06-30]	SOLE	927,558	927,558
Northern Trust Corp	[2025-06-30]	DFND	640,566	641,728
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	607,127	607,127
Goldman Sachs Group Inc	[2025-06-30]	DFND	584,349	584,519
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	528,077	580,749
Wasatch Advisors LP	[2025-06-30]	SOLE	486,936	486,936
Patient Square Capital LP	[2025-06-30]	SOLE	412,296	412,296
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