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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
ARK Investment Management LLC	[2023-03-31]	SOLE	8,951,987.0	9,837,166.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	7,940,602.0
BlackRock Inc.	[2023-03-31]	SOLE	7,189,858.0	7,348,294.0
State Street Corp	[2023-03-31]	DFND	3,349,996.0	3,539,638.0
Sumitomo Mitsui Trust Holdings, Inc.	[2023-03-31]	DFND	3,112,964.0	3,112,964.0
Nikko Asset Management Americas Inc	[2023-03-31]	SOLE	2,735,487.0	3,112,964.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	2,966,140.0
Morgan Stanley	[2023-03-31]	DFND	2,247,348.0	2,655,483.0
Federated Hermes Inc	[2023-03-31]	DFND	2,020,079.0	2,020,079.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	355,014.0	1,794,087.0
AllianceBernstein LP	[2023-03-31]	DFND	1,635,970.0	1,764,928.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,655,391.0	1,655,391.0
Viking Global Investors LP	[2023-03-31]	SOLE	1,569,545.0	1,569,545.0
Rokos Capital Management LLP	[2023-03-31]	OTR	0.0	1,389,296.0
Bank of America Corp /DE/	[2023-03-31]	DFND	28,100.0	1,341,093.0
Casdin Capital LLC	[2023-03-31]	SOLE	1,275,000.0	1,275,000.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,259,114.0	1,259,114.0
FMR LLC	[2023-03-31]	DFND	1,200,196.0	1,205,657.0
Himension Capital Singapore PTE Ltd	[2023-03-31]	SOLE	1,145,091.0	1,145,091.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	1,058,068.0	1,058,218.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	940,496.0
Chevy Chase Trust Holdings, LLC	[2023-03-31]	DFND	0.0	937,066.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	869,172.0	869,172.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	847,515.0	859,482.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	726,302.0	768,762.0
Northern Trust Corp	[2023-03-31]	DFND	50,761.0	759,739.0
Deep Track Capital LP	[2023-03-31]	SOLE	704,533.0	704,533.0
JPMorgan Chase & Co	[2023-03-31]	DFND	501,047.0	666,074.0
Bioimpact Capital LLC	[2023-03-31]	SOLE	572,459.0	572,459.0
Discovery Value Fund	[2023-03-31]	SOLE	561,561.0	561,561.0
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