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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2025-06-30]	SOLE	0	12,463,686
BlackRock, Inc.	[2025-06-30]	SOLE	10,168,152	10,956,666
JPMorgan Chase & Co	[2025-06-30]	DFND	9,732,954	10,614,513
Farallon Capital Management LLC	[2025-06-30]	OTR	4,821,809	4,821,809
State Street Corp	[2025-06-30]	DFND	2,801,878	3,317,512
Wellington Management Group LLP	[2025-06-30]	DFND	0	2,633,692
RTW Investments LP	[2025-06-30]	SOLE	2,593,645	2,593,645
Geode Capital Management LLC	[2025-06-30]	DFND	2,552,725	2,552,725
Fred Alger Management LLC	[2025-06-30]	SOLE	2,182,835	2,410,476
Franklin Resources Inc	[2025-06-30]	DFND	1,934,441	1,937,647
Invesco Ltd.	[2025-06-30]	DFND	0	1,870,685
AQR Capital Management LLC	[2025-06-30]	DFND	1,571,057	1,677,247
Castle Hook Partners LP	[2025-06-30]	SOLE	1,674,614	1,674,614
Norges Bank	[2025-06-30]	SOLE	1,644,068	1,644,068
Massachusetts Financial Services Co /MA/	[2025-06-30]	SOLE	1,611,216	1,611,216
Sofinnova Investments Inc	[2025-06-30]	SOLE	1,550,280	1,550,280
Maverick Capital Ltd	[2025-06-30]	SOLE	1,489,707	1,489,707
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,392,042	1,466,021
FMR LLC	[2025-06-30]	DFND	1,407,362	1,452,666
Capital World Investors	[2025-06-30]	DFND	1,409,650	1,409,650
Morgan Stanley	[2025-06-30]	DFND	877,360	1,388,091
Gilder Gagnon Howe & Co LLC	[2025-06-30]	SOLE	0	1,037,390
Driehaus Capital Management LLC	[2025-06-30]	SOLE	857,570	985,105
Sumitomo Mitsui Trust Group, Inc.	[2025-06-30]	DFND	972,506	972,506
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	971,068	971,091
Citadel Advisors LLC	[2025-06-30]	DFND	966,545	966,545
ARK Investment Management LLC	[2025-06-30]	SOLE	889,386	936,392
Ameriprise Financial Inc	[2025-06-30]	DFND	0	934,974
Raymond James Financial Inc	[2025-06-30]	DFND	805,012	832,482
Eversept Partners LP	[2025-06-30]	SOLE	796,375	796,375
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