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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Deerfield Management Company LP	[2025-06-30]	DFND	17,991,024	17,991,024
FMR LLC	[2025-06-30]	DFND	9,960,682	9,968,846
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	5,269,433	5,269,433
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,421,568
BlackRock, Inc.	[2025-06-30]	SOLE	3,933,305	4,045,830
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,782,581
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,576,374
State Street Corp	[2025-06-30]	DFND	1,383,507	1,490,279
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	1,447,267	1,447,267
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,375,180	1,375,180
Commodore Capital LP	[2025-06-30]	SOLE	1,375,000	1,375,000
JPMorgan Chase & Co	[2025-06-30]	DFND	1,092,783	1,196,969
Braidwell LP	[2025-06-30]	SOLE	1,175,876	1,175,876
Vestal Point Capital LP	[2025-06-30]	SOLE	1,075,000	1,075,000
Geode Capital Management LLC	[2025-06-30]	DFND	996,845	996,845
Woodline Partners LP	[2025-06-30]	SOLE	904,232	904,232
Polar Capital Holdings Plc	[2025-06-30]	DFND	816,087	816,087
Fairmount Funds Management LLC	[2025-06-30]	SOLE	727,563	727,563
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	530,734	589,832
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	577,500	577,500
Goldman Sachs Group Inc	[2025-06-30]	DFND	533,740	535,445
Ameriprise Financial Inc	[2025-06-30]	DFND	0	484,343
Morgan Stanley	[2025-06-30]	DFND	420,680	422,722
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	415,000	415,000
American Century Companies Inc	[2025-06-30]	DFND	314,134	374,698
Norges Bank	[2025-06-30]	SOLE	374,597	374,597
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	369,858	369,858
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	346,496	346,506
Northern Trust Corp	[2025-06-30]	DFND	335,126	335,126
First TURN Management LLC	[2025-06-30]	SOLE	320,798	320,798
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