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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	2,599,398	2,600,385
PFM Health Sciences LP	[2025-06-30]	DFND	0	1,664,727
Durable Capital Partners LP	[2025-06-30]	SOLE	1,657,126	1,657,126
Alyeska Investment Group LP	[2025-06-30]	SOLE	1,464,582	1,464,582
Woodline Partners LP	[2025-06-30]	SOLE	1,325,784	1,325,784
BlackRock, Inc.	[2025-06-30]	SOLE	962,028	983,891
Vanguard Group Inc	[2025-06-30]	SOLE	0	972,310
Perceptive Advisors LLC	[2025-06-30]	SOLE	833,333	833,333
Massachusetts Financial Services Co /MA/	[2025-06-30]	SOLE	636,333	636,333
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	549,052	549,052
Marshall Wace LLP	[2025-06-30]	OTR	0	521,400
Pura Vida Investments LLC	[2025-06-30]	SOLE	429,120	429,120
Geode Capital Management LLC	[2025-06-30]	DFND	415,552	415,552
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	314,522	314,522
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	256,682	256,682
Northern Trust Corp	[2025-06-30]	DFND	246,642	246,642
State Street Corp	[2025-06-30]	DFND	181,062	205,270
Catalio Capital Management LP	[2025-06-30]	SOLE	166,666	166,666
Millennium Management LLC	[2025-06-30]	SOLE	158,535	158,535
Balyasny Asset Management LP	[2025-06-30]	SOLE	143,160	143,160
Bank of America Corp /DE/	[2025-06-30]	DFND	2,491	135,890
Morgan Stanley	[2025-06-30]	DFND	121,068	121,370
GMT Capital Corp	[2025-06-30]	SOLE	98,108	98,108
Goldman Sachs Group Inc	[2025-06-30]	DFND	92,122	92,122
UBS Group AG	[2025-06-30]	DFND	79,556	79,586
Two Sigma Investments LP	[2025-06-30]	SOLE	74,094	74,094
C WorldWide Group Holding A/S	[2025-06-30]	DFND	66,666	66,666
Walleye Capital LLC	[2025-06-30]	SOLE	56,101	56,101
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	55,660	55,660
TD Asset Management Inc	[2025-06-30]	SOLE	53,266	53,266
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