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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Takeda Pharmaceutical Co Ltd	[2025-06-30]	DFND	5,750,000	5,750,000
BVF Inc/IL	[2025-06-30]	DFND	0	3,853,818
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,612,376
SIO Capital Management LLC	[2025-06-30]	SOLE	2,232,000	2,232,000
Acadian Asset Management LLC	[2025-06-30]	DFND	2,108,336	2,108,336
Renaissance Technologies LLC	[2025-06-30]	SOLE	2,095,309	2,095,309
Takeda Pharmaceutical Co Ltd	[2025-06-30]	SOLE	1,781,996	1,781,996
Kennedy Capital Management LLC	[2025-06-30]	SOLE	1,502,329	1,502,329
Driehaus Capital Management LLC	[2025-06-30]	SOLE	1,400,191	1,400,191
BlackRock, Inc.	[2025-06-30]	SOLE	1,359,560	1,369,010
Madison Avenue Partners LP	[2025-06-30]	SOLE	1,311,362	1,311,362
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,150,000	1,150,000
Millennium Management LLC	[2025-06-30]	SOLE	1,052,334	1,052,334
Wells Fargo & Company/MN	[2025-06-30]	DFND	1,311	763,114
GSA Capital Partners LLP	[2025-06-30]	SOLE	742,190	742,190
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	667,516	667,516
Geode Capital Management LLC	[2025-06-30]	DFND	643,335	643,335
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	500,000	500,000
Rubric Capital Management LP	[2025-06-30]	SOLE	478,533	478,533
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	435,620	435,620
Goldman Sachs Group Inc	[2025-06-30]	DFND	283,824	283,824
Susquehanna International Group LLP	[2025-06-30]	OTR	230,245	230,245
State Street Corp	[2025-06-30]	DFND	227,033	227,033
Squarepoint Ops LLC	[2025-06-30]	DFND	0	221,126
Marshall Wace LLP	[2025-06-30]	OTR	0	164,721
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	160,306	160,306
Velan Capital Investment Management LP	[2025-06-30]	SOLE	160,000	160,000
Jane Street Group LLC	[2025-06-30]	DFND	142,597	142,597
HRT Financial LP	[2025-06-30]	DFND	123,316	123,316
Adar1 Capital Management LLC	[2025-06-30]	SOLE	115,867	115,867
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