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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	10,689,545	10,689,545
Point72 Asset Management LP	[2025-06-30]	DFND	0	2,759,171
Millennium Management LLC	[2025-06-30]	SOLE	1,509,198	1,509,198
Viking Global Investors LP	[2025-06-30]	SOLE	1,482,434	1,482,434
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,350,000	1,350,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	930,259
Laurion Capital Management LP	[2025-06-30]	SOLE	810,761	810,761
Woodline Partners LP	[2025-06-30]	SOLE	691,530	691,530
BlackRock, Inc.	[2025-06-30]	SOLE	645,990	648,021
Suvretta Capital Management LLC	[2025-06-30]	SOLE	300,000	300,000
ProSight Management LP	[2025-06-30]	SOLE	243,980	243,980
Opaleye Management Inc	[2025-06-30]	SOLE	240,000	240,000
Geode Capital Management LLC	[2025-06-30]	DFND	201,096	201,096
Sphera Funds Management Ltd	[2025-06-30]	DFND	156,467	156,467
Ikarian Capital LLC	[2025-06-30]	SOLE	150,000	150,000
RBF Capital, LLC	[2025-06-30]	SOLE	100,000	100,000
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	91,923	91,923
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	73,004	73,004
Goldman Sachs Group Inc	[2025-06-30]	DFND	70,603	70,603
State Street Corp	[2025-06-30]	DFND	69,140	69,140
Morgan Stanley	[2025-06-30]	DFND	64,520	64,838
Two Sigma Investments LP	[2025-06-30]	SOLE	63,740	63,740
Renaissance Technologies LLC	[2025-06-30]	SOLE	51,300	51,300
Northern Trust Corp	[2025-06-30]	DFND	47,986	47,986
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	45,570
Susquehanna International Group LLP	[2025-06-30]	OTR	42,305	42,305
Marshall Wace LLP	[2025-06-30]	OTR	0	39,209
Zacks Investment Management	[2025-06-30]	SOLE	38,047	38,047
Rangeley Capital LLC	[2025-06-30]	SOLE	35,000	35,000
AQR Capital Management LLC	[2025-06-30]	DFND	32,030	32,030
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