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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	8,407,152.0	8,407,152.0
Carlyle Group Inc.	[2023-03-31]	DFND	0.0	2,935,106.0
Medicxi Ventures Management (Jersey) Ltd	[2023-03-31]	SOLE	2,484,274.0	2,484,274.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	2,181,672.0
Avidity Partners Management LP	[2023-03-31]	SOLE	2,048,600.0	2,048,600.0
Ensign Peak Advisors, Inc	[2023-03-31]	SOLE	1,761,191.0	1,761,191.0
BlackRock Inc.	[2023-03-31]	SOLE	1,613,718.0	1,632,910.0
683 Capital Management LLC	[2023-03-31]	DFND	1,325,500.0	1,325,500.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,118,262.0
Newtyn Management LLC	[2023-03-31]	SOLE	682,027.0	682,027.0
GW&K Investment Management LLC	[2023-03-31]	SOLE	598,848.0	598,848.0
Gilder Gagnon Howe & Co LLC	[2023-03-31]	DFND	0.0	553,829.0
Opaleye Management Inc	[2023-03-31]	SOLE	496,000.0	496,000.0
State Street Corp	[2023-03-31]	DFND	426,607.0	463,743.0
Geode Capital Management LLC	[2023-03-31]	DFND	448,611.0	448,611.0
StepStone Group LP	[2023-03-31]	DFND	422,085.0	422,085.0
Susquehanna International Group LLP	[2023-03-31]	DFND	146,416.0	338,116.0
Bank of America Corp /DE/	[2023-03-31]	DFND	32,959.0	253,485.0
Simplify Asset Management Inc	[2023-03-31]	SOLE	237,935.0	237,935.0
Citadel Advisors LLC	[2023-03-31]	DFND	234,084.0	234,084.0
Northern Trust Corp	[2023-03-31]	DFND	8,287.0	212,901.0
Bioimpact Capital LLC	[2023-03-31]	SOLE	212,615.0	212,615.0
SilverArc Capital Management LLC	[2023-03-31]	SOLE	200,000.0	200,000.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	171,607.0	171,607.0
JPMorgan Chase & Co	[2023-03-31]	DFND	114,699.0	133,587.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	108,284.0	108,284.0
UBS OConnor LLC	[2023-03-31]	DFND	100,093.0	100,093.0
State of Wisconsin Investment Board	[2023-03-31]	SOLE	95,167.0	95,167.0
Morgan Stanley	[2023-03-31]	DFND	92,046.0	93,698.0
Atom Investors LP	[2023-03-31]	SOLE	86,607.0	86,607.0
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