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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Deerfield Management Company LP	[2025-06-30]	DFND	2,494,108	2,494,108
Nantahala Capital Management LLC	[2025-06-30]	SOLE	2,493,309	2,493,309
Morgan Stanley	[2025-06-30]	DFND	1,854,032	1,854,032
AIGH Capital Management LLC	[2025-06-30]	SOLE	1,182,923	1,182,923
Ikarian Capital LLC	[2025-06-30]	SOLE	892,976	892,976
JPMorgan Chase & Co	[2025-06-30]	DFND	430,000	430,000
DAFNA Capital Management LLC	[2025-06-30]	SOLE	401,136	401,136
AIGH Capital Management LLC	[2025-06-30]	OTR	0	384,021
Adar1 Capital Management LLC	[2025-06-30]	SOLE	299,598	299,598
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	237,376
Johnson & Johnson	[2025-06-30]	DFND	0	96,866
Warberg Asset Management LLC	[2025-06-30]	SOLE	80,000	80,000
Renaissance Technologies LLC	[2025-06-30]	SOLE	25,300	25,300
Barclays PLC	[2025-06-30]	DFND	0	25,000
XTX Topco Ltd	[2025-06-30]	DFND	24,893	24,893
Two Sigma Securities LLC	[2025-06-30]	SOLE	10,555	10,555
Clear Street LLC	[2025-06-30]	SOLE	2,263	2,263
SBI Securities Co., Ltd.	[2025-06-30]	DFND	400	400
Carolina Wealth Advisors LLC	[2025-06-30]	SOLE	0	159
Bank of America Corp /DE/	[2025-06-30]	DFND	0	1
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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