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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2023-03-31]	SOLE	3,161,489.0	3,161,489.0
Johnson & Johnson	[2023-03-31]	DFND	0.0	2,133,402.0
MMCAP International Inc. SPC	[2023-03-31]	SOLE	608,162.0	608,162.0
Susquehanna International Group LLP	[2023-03-31]	DFND	195,598.0	195,598.0
J Goldman & Co LP	[2023-03-31]	SOLE	150,000.0	150,000.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	78,300.0	78,300.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	49,500.0	49,500.0
Millennium Management LLC	[2023-03-31]	SOLE	33,266.0	33,266.0
Citadel Advisors LLC	[2023-03-31]	DFND	30,475.0	30,475.0
Walleye Capital LLC	[2023-03-31]	SOLE	21,056.0	21,056.0
Walleye Trading LLC	[2023-03-31]	SOLE	10,422.0	10,422.0
BlackRock Inc.	[2023-03-31]	SOLE	5,750.0	5,750.0
UBS Group AG	[2023-03-31]	SOLE	3,003.0	3,003.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	1.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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