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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2023-03-31]	SOLE	6,563,077.0	6,563,077.0
BlackRock Inc.	[2023-03-31]	SOLE	3,910,327.0	4,030,169.0
JPMorgan Chase & Co	[2023-03-31]	DFND	3,690,944.0	4,002,884.0
Boxer Capital, LLC	[2023-03-31]	OTR	3,163,795.0	3,163,795.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	3,060,000.0	3,060,000.0
RTW Investments LP	[2023-03-31]	SOLE	2,999,098.0	2,999,098.0
Euclidean Capital LLC	[2023-03-31]	SOLE	2,336,909.0	2,336,909.0
Verition Fund Management LLC	[2023-03-31]	SOLE	2,147,351.0	2,147,351.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,920,425.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,782,004.0	1,782,004.0
InterWest Venture Management Co	[2023-03-31]	SOLE	1,614,911.0	1,614,911.0
Alkeon Capital Management LLC	[2023-03-31]	SOLE	1,168,336.0	1,168,336.0
OUP Management Co LLC	[2023-03-31]	SOLE	989,232.0	989,232.0
Bank of America Corp /DE/	[2023-03-31]	DFND	7,611.0	931,698.0
Principal Financial Group Inc	[2023-03-31]	DFND	917,885.0	917,885.0
ArrowMark Colorado Holdings LLC	[2023-03-31]	SOLE	899,561.0	899,561.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	870,054.0
State Street Corp	[2023-03-31]	DFND	736,300.0	775,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	666,111.0	666,111.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	638,045.0	638,045.0
Morgan Stanley	[2023-03-31]	DFND	525,972.0	630,259.0
Personal CFO Solutions LLC	[2023-03-31]	SOLE	0.0	550,342.0
Nextech Invest Ltd	[2023-03-31]	SOLE	521,284.0	521,284.0
Federated Hermes Inc	[2023-03-31]	DFND	498,263.0	498,263.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	420,824.0	420,824.0
PFM Health Sciences LP	[2023-03-31]	DFND	0.0	418,027.0
Susquehanna International Group LLP	[2023-03-31]	DFND	340,983.0	393,583.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	326,486.0	370,338.0
Millennium Management LLC	[2023-03-31]	SOLE	342,152.0	342,152.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	322,024.0	322,024.0
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