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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2025-06-30]	SOLE	6,475,291	6,475,291
BML Capital Management LLC	[2025-06-30]	SOLE	0	5,000,000
SIO Capital Management LLC	[2025-06-30]	SOLE	3,735,396	3,735,396
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	3,188,116	3,188,116
Euclidean Capital LLC	[2025-06-30]	SOLE	2,627,643	2,627,643
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,132,041
Acadian Asset Management LLC	[2025-06-30]	DFND	2,066,137	2,066,137
Alkeon Capital Management LLC	[2025-06-30]	SOLE	1,961,774	1,961,774
BlackRock, Inc.	[2025-06-30]	SOLE	1,140,592	1,140,592
Stonepine Capital Management LLC	[2025-06-30]	SOLE	845,968	845,968
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	646,229	647,629
Aldebaran Capital LLC	[2025-06-30]	SOLE	515,128	515,128
Two Sigma Advisers LP	[2025-06-30]	SOLE	469,800	485,700
Peapod Lane Capital LLC	[2025-06-30]	SOLE	355,627	452,682
Geode Capital Management LLC	[2025-06-30]	DFND	432,704	432,704
Alkeon Capital Management LLC	[2025-06-30]	DFND	0	380,599
Two Sigma Investments LP	[2025-06-30]	SOLE	291,455	291,455
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	263,059	263,059
Citadel Advisors LLC	[2025-06-30]	DFND	256,431	256,431
RBF Capital, LLC	[2025-06-30]	SOLE	245,561	245,561
State Street Corp	[2025-06-30]	DFND	157,578	157,578
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	148,800	148,800
Evoke Wealth LLC	[2025-06-30]	SOLE	0	133,122
UBS Group AG	[2025-06-30]	DFND	122,310	122,310
Northern Trust Corp	[2025-06-30]	DFND	115,657	115,657
Adar1 Capital Management LLC	[2025-06-30]	SOLE	101,008	101,008
Goldman Sachs Group Inc	[2025-06-30]	DFND	95,073	95,073
PanAgora Asset Management Inc	[2025-06-30]	SOLE	86,920	86,920
Walleye Capital LLC	[2025-06-30]	SOLE	77,887	77,887
PNC Financial Services Group Inc	[2025-06-30]	DFND	60,127	60,127
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