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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Merck & Co., Inc.	[2025-06-30]	DFND	0	14,044,943
Lightspeed Management Company LLC	[2025-06-30]	SOLE	8,160,734	8,160,734
ARK Investment Management LLC	[2025-06-30]	SOLE	7,107,923	7,107,923
BlackRock, Inc.	[2025-06-30]	SOLE	4,947,738	5,203,993
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,087,439
AIGH Capital Management LLC	[2025-06-30]	SOLE	2,785,350	2,785,350
Aberdeen Group plc	[2025-06-30]	DFND	1,759,497	1,759,497
Blue Water Life Science Advisors LP	[2025-06-30]	SOLE	1,676,300	1,676,300
Geode Capital Management LLC	[2025-06-30]	DFND	1,365,598	1,365,598
Millennium Management LLC	[2025-06-30]	SOLE	1,090,727	1,090,727
AIGH Capital Management LLC	[2025-06-30]	OTR	0	938,608
State Street Corp	[2025-06-30]	DFND	616,384	687,584
Kennedy Capital Management LLC	[2025-06-30]	SOLE	653,383	653,383
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	617,754	645,106
Sumitomo Mitsui Trust Group, Inc.	[2025-06-30]	DFND	640,420	640,420
Nuveen, LLC	[2025-06-30]	DFND	634,380	635,571
Nikko Asset Management Americas Inc	[2025-06-30]	SOLE	0	634,317
Morgan Stanley	[2025-06-30]	DFND	528,467	626,459
Renaissance Technologies LLC	[2025-06-30]	SOLE	563,243	563,243
State of Michigan Retirement System	[2025-06-30]	SOLE	493,798	493,798
Wellington Shields Capital Management LLC	[2025-06-30]	SOLE	0	426,331
Northern Trust Corp	[2025-06-30]	DFND	392,318	392,318
Ameriprise Financial Inc	[2025-06-30]	DFND	0	329,865
Wellington Shields & Co LLC	[2025-06-30]	SOLE	0	292,489
Howland Capital Management LLC	[2025-06-30]	SOLE	40,400	285,308
Bruce & Co Inc	[2025-06-30]	SOLE	253,000	253,000
Perkins Capital Management Inc	[2025-06-30]	SOLE	227,500	252,500
Bank of America Corp /DE/	[2025-06-30]	DFND	7,209	222,011
Goldman Sachs Group Inc	[2025-06-30]	DFND	209,666	209,666
Susquehanna International Group LLP	[2025-06-30]	OTR	63,796	199,696
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