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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	722,400	722,400
Suvretta Capital Management LLC	[2025-06-30]	SOLE	714,463	714,463
BVF Inc/IL	[2025-06-30]	DFND	0	696,555
Woodline Partners LP	[2025-06-30]	SOLE	445,615	445,615
BlackRock, Inc.	[2025-06-30]	SOLE	438,791	445,052
Samsara Biocapital LLC	[2025-06-30]	SOLE	339,743	339,743
Millennium Management LLC	[2025-06-30]	SOLE	314,989	314,989
Adams Street Partners LLC	[2025-06-30]	SOLE	298,986	298,986
Nantahala Capital Management LLC	[2025-06-30]	SOLE	250,062	250,062
Geode Capital Management LLC	[2025-06-30]	DFND	173,986	173,986
Vanguard Group Inc	[2025-06-30]	SOLE	0	153,476
Morgan Stanley	[2025-06-30]	DFND	28,950	135,754
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	125,259
Sectoral Asset Management Inc	[2025-06-30]	SOLE	0	95,615
CLIO Asset Management LLC	[2025-06-30]	SOLE	0	91,508
Goldman Sachs Group Inc	[2025-06-30]	DFND	85,329	85,329
State Street Corp	[2025-06-30]	DFND	75,027	82,011
Royce & Associates LP	[2025-06-30]	SOLE	74,516	74,516
AWM Investment Company Inc	[2025-06-30]	SOLE	69,416	69,416
Renaissance Technologies LLC	[2025-06-30]	SOLE	66,858	66,858
J Goldman & Co LP	[2025-06-30]	SOLE	56,290	56,290
Northern Trust Corp	[2025-06-30]	DFND	53,453	53,453
Marshall Wace LLP	[2025-06-30]	OTR	0	49,077
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AM	[2025-06-30]	DFND	43,994	43,994
DAFNA Capital Management LLC	[2025-06-30]	SOLE	43,348	43,348
UBS Group AG	[2025-06-30]	DFND	43,149	43,149
Susquehanna International Group LLP	[2025-06-30]	OTR	17,384	27,284
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	21,013	21,013
Cresset Asset Management LLC	[2025-06-30]	SOLE	20,911	20,911
Strid Group LLC	[2025-06-30]	SOLE	0	18,166
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