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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2025-06-30]	SOLE	5,158,231	5,158,231
EcoR1 Capital LLC	[2025-06-30]	SOLE	4,123,971	4,123,971
Vestal Point Capital LP	[2025-06-30]	SOLE	3,700,000	3,700,000
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	3,625,000	3,625,000
Aberdeen Group plc	[2025-06-30]	DFND	2,750,714	2,750,714
Jefferies Financial Group Inc.	[2025-06-30]	DFND	2,095,931	2,095,931
Nantahala Capital Management LLC	[2025-06-30]	SOLE	2,051,852	2,051,852
Caption Management LLC	[2025-06-30]	SOLE	2,018,511	2,018,511
JPMorgan Chase & Co	[2025-06-30]	DFND	1,641,967	1,807,685
Susquehanna International Group LLP	[2025-06-30]	OTR	48,283	1,792,783
Franklin Resources Inc	[2025-06-30]	DFND	1,605,515	1,605,515
Sofinnova Investments Inc	[2025-06-30]	SOLE	1,558,356	1,558,356
Integral Health Asset Management LLC	[2025-06-30]	SOLE	1,350,000	1,350,000
BlackRock, Inc.	[2025-06-30]	SOLE	1,308,542	1,333,663
683 Capital Management LLC	[2025-06-30]	DFND	1,322,500	1,322,500
FMR LLC	[2025-06-30]	DFND	1,181,293	1,184,362
State Street Corp	[2025-06-30]	DFND	1,142,430	1,142,810
Two Sigma Investments LP	[2025-06-30]	SOLE	940,960	940,960
Vanguard Group Inc	[2025-06-30]	SOLE	0	919,230
Morgan Stanley	[2025-06-30]	DFND	901,376	908,283
Boxer Capital Management LLC	[2025-06-30]	SOLE	0	899,500
Citadel Advisors LLC	[2025-06-30]	DFND	813,365	813,365
Ameriprise Financial Inc	[2025-06-30]	DFND	0	761,948
Macquarie Group Ltd	[2025-06-30]	SOLE	706,166	706,166
Schroder Investment Management Group	[2025-06-30]	SOLE	693,283	693,283
Two Sigma Advisers LP	[2025-06-30]	SOLE	627,700	659,700
Geode Capital Management LLC	[2025-06-30]	DFND	603,210	603,210
Stempoint Capital LP	[2025-06-30]	SOLE	508,220	572,615
Balyasny Asset Management LP	[2025-06-30]	SOLE	536,968	536,968
Pale Fire Capital SE	[2025-06-30]	DFND	0	529,798
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