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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock Inc.	[2023-03-31]	SOLE	7,727,210.0	8,040,790.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	4,245,601.0
JPMorgan Chase & Co	[2023-03-31]	DFND	3,647,733.0	4,005,623.0
State Street Corp	[2023-03-31]	DFND	2,491,970.0	2,581,263.0
Redmile Group LLC	[2023-03-31]	SOLE	1,640,725.0	1,640,725.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	1,383,514.0	1,435,315.0
Aquilo Capital Management LLC	[2023-03-31]	SOLE	831,014.0	831,014.0
Citadel Advisors LLC	[2023-03-31]	DFND	764,957.0	764,957.0
Geode Capital Management LLC	[2023-03-31]	DFND	760,797.0	760,797.0
Millennium Management LLC	[2023-03-31]	SOLE	719,211.0	719,211.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	559,646.0	632,378.0
Bioimpact Capital LLC	[2023-03-31]	SOLE	617,671.0	617,671.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	602,837.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	516,785.0	556,711.0
First Manhattan Co LLC	[2023-03-31]	SOLE	437,130.0	447,730.0
Northern Trust Corp	[2023-03-31]	DFND	19,804.0	410,053.0
WS Management LLLP	[2023-03-31]	SOLE	396,997.0	396,997.0
American Century Companies Inc	[2023-03-31]	DFND	380,751.0	380,751.0
Balyasny Asset Management LP	[2023-03-31]	SOLE	375,608.0	375,608.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	319,023.0	344,588.0
Morgan Stanley	[2023-03-31]	DFND	224,654.0	328,565.0
Woodline Partners LP	[2023-03-31]	SOLE	305,822.0	305,822.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	293,508.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	289,607.0	289,607.0
Principal Financial Group Inc	[2023-03-31]	DFND	242,026.0	242,026.0
ArchPoint Investors	[2023-03-31]	SOLE	224,278.0	224,278.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	198,630.0	198,630.0
Bank of America Corp /DE/	[2023-03-31]	DFND	8,760.0	198,250.0
Sonic GP LLC	[2023-03-31]	SOLE	193,079.0	193,079.0
Royce & Associates LP	[2023-03-31]	SOLE	182,450.0	182,450.0
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