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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	6,241,168	6,759,093
Redmile Group LLC	[2025-06-30]	SOLE	4,775,717	4,775,717
JPMorgan Chase & Co	[2025-06-30]	DFND	3,460,946	3,852,025
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,386,145
State Street Corp	[2025-06-30]	DFND	1,778,592	1,843,645
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,783,641	1,784,506
Geode Capital Management LLC	[2025-06-30]	DFND	1,128,521	1,128,521
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,011,339	1,060,414
Morgan Stanley	[2025-06-30]	DFND	772,197	994,756
22NW LP	[2025-06-30]	SOLE	923,679	923,679
AQR Capital Management LLC	[2025-06-30]	DFND	878,867	904,426
Balyasny Asset Management LP	[2025-06-30]	SOLE	797,100	797,100
Renaissance Technologies LLC	[2025-06-30]	SOLE	735,200	735,200
Integral Health Asset Management LLC	[2025-06-30]	SOLE	700,000	700,000
Voss Capital LP	[2025-06-30]	SOLE	575,000	575,000
Bank of America Corp /DE/	[2025-06-30]	DFND	11,501	572,499
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	572,461	572,461
Trexquant Investment LP	[2025-06-30]	SOLE	560,364	560,364
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	457,112	457,112
Nuveen, LLC	[2025-06-30]	DFND	419,102	420,249
Northern Trust Corp	[2025-06-30]	DFND	392,911	392,911
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	387,503	387,503
Ameriprise Financial Inc	[2025-06-30]	DFND	0	372,849
Citadel Advisors LLC	[2025-06-30]	DFND	338,566	338,566
Stifel Financial Corp	[2025-06-30]	DFND	307,026	311,107
UBS Group AG	[2025-06-30]	DFND	273,650	307,874
Jane Street Group LLC	[2025-06-30]	DFND	242,412	271,612
Acadian Asset Management LLC	[2025-06-30]	DFND	240,264	240,264
GSA Capital Partners LLP	[2025-06-30]	SOLE	226,582	226,582
Exome Asset Management LLC	[2025-06-30]	SOLE	226,060	226,060
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