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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	3,052,796.0
Artisan Partners Limited Partnership	[2023-03-31]	SOLE	2,084,300.0	2,646,641.0
BlackRock Inc.	[2023-03-31]	SOLE	1,237,586.0	1,247,809.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	279,100.0	1,202,833.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	979,364.0
Next Century Growth Investors LLC	[2023-03-31]	SOLE	876,563.0	876,563.0
Millennium Management LLC	[2023-03-31]	SOLE	683,271.0	683,271.0
JPMorgan Chase & Co	[2023-03-31]	DFND	450,315.0	565,506.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	390,835.0	469,890.0
Parkman Healthcare Partners LLC	[2023-03-31]	SOLE	427,793.0	427,793.0
Geode Capital Management LLC	[2023-03-31]	DFND	398,839.0	398,839.0
State Street Corp	[2023-03-31]	DFND	345,481.0	367,921.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	348,168.0
Lord Abbett & Co LLC	[2023-03-31]	SOLE	251,915.0	334,889.0
Northern Trust Corp	[2023-03-31]	DFND	4,435.0	184,577.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	132,899.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	123,400.0	123,400.0
New York State Common Retirement Fund	[2023-03-31]	SOLE	114,441.0	114,441.0
Belpointe Asset Management LLC	[2023-03-31]	SOLE	105,250.0	105,250.0
Bridger Management LLC	[2023-03-31]	SOLE	99,100.0	99,100.0
Magnetar Financial LLC	[2023-03-31]	SOLE	88,236.0	88,236.0
Soleus Capital Management LP	[2023-03-31]	SOLE	80,000.0	80,000.0
Citadel Advisors LLC	[2023-03-31]	DFND	77,920.0	77,920.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	76,959.0	76,969.0
Polar Asset Management Partners Inc	[2023-03-31]	SOLE	75,181.0	75,181.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	67,352.0	67,352.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	61,461.0	65,658.0
Russell Investments Group, Ltd.	[2023-03-31]	DFND	36,114.0	63,100.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	60,776.0	60,776.0
Bradley Foster & Sargent Inc/Ct	[2023-03-31]	SOLE	55,084.0	57,334.0
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