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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Broadwood Capital Inc	[2025-06-30]	DFND	13,519,491	13,519,491
BlackRock, Inc.	[2025-06-30]	SOLE	7,219,559	7,371,147
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,286,971
Soleus Capital Management LP	[2025-06-30]	SOLE	2,984,733	2,984,733
Armistice Capital LLC	[2025-06-30]	SOLE	2,812,000	2,812,000
Resona Asset Management Co.,Ltd.	[2025-06-30]	OTR	2,421,836	2,421,836
Yunqi Capital Ltd	[2025-06-30]	SOLE	2,411,288	2,411,288
State Street Corp	[2025-06-30]	DFND	1,879,836	2,002,876
Morgan Stanley	[2025-06-30]	DFND	1,170,596	1,312,303
Geode Capital Management LLC	[2025-06-30]	DFND	1,192,821	1,192,821
Bank of America Corp /DE/	[2025-06-30]	DFND	9,287	1,153,895
Palo Alto Investors LP	[2025-06-30]	SOLE	791,879	791,879
American Capital Management Inc	[2025-06-30]	SOLE	478,023	784,914
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	663,603	720,557
Defender Capital LLC	[2025-06-30]	SOLE	0	695,764
Citadel Advisors LLC	[2025-06-30]	DFND	665,716	665,716
Jupiter Asset Management Ltd	[2025-06-30]	SOLE	519,394	519,394
Northern Trust Corp	[2025-06-30]	DFND	485,148	486,539
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	474,241	474,281
Two Sigma Investments LP	[2025-06-30]	SOLE	407,381	407,381
Federated Hermes Inc	[2025-06-30]	DFND	363,233	363,233
Bank of New York Mellon Corp	[2025-06-30]	DFND	285,598	306,688
Voloridge Investment Management LLC	[2025-06-30]	SOLE	293,080	293,080
Principal Financial Group Inc	[2025-06-30]	DFND	291,568	291,568
UBS Group AG	[2025-06-30]	DFND	267,558	267,674
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	248,394	248,394
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	243,470
Jump Financial, LLC	[2025-06-30]	DFND	240,585	240,585
Legal & General Group Plc	[2025-06-30]	DFND	196,667	205,965
Susquehanna Portfolio Strategies, LLC	[2025-06-30]	SOLE	188,688	188,688
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