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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Broadwood Capital Inc	[2023-03-31]	DFND	8,783,082.0	8,783,082.0
BlackRock Inc.	[2023-03-31]	SOLE	5,786,475.0	5,852,539.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	5,001,566.0
Baillie Gifford & Co	[2023-03-31]	DFND	2,926,140.0	3,662,825.0
Anatole Investment Management Ltd	[2023-03-31]	SOLE	2,042,744.0	2,042,744.0
State Street Corp	[2023-03-31]	DFND	1,578,360.0	1,683,144.0
Baillie Gifford & Co	[2023-03-31]	SOLE	1,130,125.0	1,461,516.0
Palo Alto Investors LP	[2023-03-31]	SOLE	1,347,322.0	1,347,322.0
Geode Capital Management LLC	[2023-03-31]	DFND	933,404.0	941,611.0
E Fund Management Co., Ltd.	[2023-03-31]	SOLE	902,296.0	902,296.0
Yong Rong (HK) Asset Management Ltd	[2023-03-31]	SOLE	696,230.0	696,230.0
Principal Financial Group Inc	[2023-03-31]	DFND	677,715.0	677,715.0
Geneva Capital Management LLC	[2023-03-31]	SOLE	603,820.0	618,303.0
Northern Trust Corp	[2023-03-31]	DFND	31,927.0	609,812.0
Clearbridge Investments LLC	[2023-03-31]	SOLE	540,105.0	540,218.0
APEIRON CAPITAL Ltd	[2023-03-31]	SOLE	523,025.0	523,025.0
Kayne Anderson Rudnick Investment Management LLC	[2023-03-31]	DFND	0.0	521,778.0
Defender Capital LLC	[2023-03-31]	SOLE	491,497.0	491,497.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	463,995.0	482,944.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	453,540.0	460,948.0
Ensign Peak Advisors, Inc	[2023-03-31]	SOLE	446,517.0	446,517.0
CloudAlpha Capital Management Limited/Hong Kong	[2023-03-31]	SOLE	440,300.0	440,300.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	392,370.0	392,370.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	387,120.0	387,120.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	307,902.0	341,105.0
Geneva Capital Management LLC	[2023-03-31]	OTR	339,554.0	339,554.0
Loomis Sayles & Co L P	[2023-03-31]	DFND	330,770.0	335,738.0
Bank of America Corp /DE/	[2023-03-31]	DFND	56,890.0	333,593.0
Morgan Stanley	[2023-03-31]	DFND	162,923.0	332,202.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	272,845.0	296,700.0
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