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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	9,116,463	9,366,922
Vanguard Group Inc	[2025-06-30]	SOLE	0	6,099,416
Armistice Capital LLC	[2025-06-30]	SOLE	4,812,000	4,812,000
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	2,826,208	2,896,354
Macquarie Group Ltd	[2025-06-30]	SOLE	2,687,414	2,762,124
State Street Corp	[2025-06-30]	DFND	2,032,122	2,208,560
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,655,322	1,655,322
Stephens Investment Management Group LLC	[2025-06-30]	DFND	0	1,581,093
Geode Capital Management LLC	[2025-06-30]	DFND	1,399,610	1,399,610
Loomis Sayles & Co L P	[2025-06-30]	DFND	1,261,497	1,297,858
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,002,340	1,002,340
American Century Companies Inc	[2025-06-30]	DFND	916,154	916,154
Goldman Sachs Group Inc	[2025-06-30]	DFND	836,936	883,901
Aristotle Capital Boston LLC	[2025-06-30]	SOLE	808,395	808,395
Sofinnova Investments Inc	[2025-06-30]	SOLE	799,253	799,253
Woodline Partners LP	[2025-06-30]	SOLE	772,976	772,976
Victory Capital Management Inc	[2025-06-30]	SOLE	658,320	751,543
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	748,608	748,641
Rubric Capital Management LP	[2025-06-30]	SOLE	695,039	695,039
Morgan Stanley	[2025-06-30]	DFND	563,318	693,752
Northern Trust Corp	[2025-06-30]	DFND	678,978	681,133
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	597,726	598,621
Ashford Capital Management Inc	[2025-06-30]	SOLE	574,372	574,372
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	548,741	554,482
Rice Hall James & Associates LLC	[2025-06-30]	SOLE	426,601	524,647
Point72 Asset Management LP	[2025-06-30]	DFND	0	507,790
Bank of America Corp /DE/	[2025-06-30]	DFND	19,505	504,306
Krensavage Asset Management LLC	[2025-06-30]	SOLE	472,376	472,376
Invesco Ltd.	[2025-06-30]	DFND	0	399,019
Bank of New York Mellon Corp	[2025-06-30]	DFND	359,926	397,378
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