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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Lynx1 Capital Management LP	[2025-06-30]	OTR	0	7,857,347
BVF Inc/IL	[2025-06-30]	DFND	0	5,226,074
Baker Bros Advisors LP	[2025-06-30]	SOLE	2,784,792	2,784,792
BlackRock, Inc.	[2025-06-30]	SOLE	2,310,368	2,566,524
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,133,671
Propel Bio Management LLC	[2025-06-30]	DFND	1,040,223	2,087,139
Deer Management Co LLC	[2025-06-30]	DFND	1,245,504	1,245,504
Alphabet Inc.	[2025-06-30]	DFND	0	1,077,080
Simplify Asset Management Inc	[2025-06-30]	SOLE	1,046,916	1,046,916
Aberdeen Group plc	[2025-06-30]	DFND	891,448	891,448
Morgan Stanley	[2025-06-30]	DFND	733,269	853,346
Renaissance Technologies LLC	[2025-06-30]	SOLE	792,056	792,056
Millennium Management LLC	[2025-06-30]	SOLE	630,138	630,138
DC Funds, LP	[2025-06-30]	SOLE	630,000	630,000
Tang Capital Management LLC	[2025-06-30]	OTR	0	600,000
Geode Capital Management LLC	[2025-06-30]	DFND	566,371	566,371
Goldman Sachs Group Inc	[2025-06-30]	DFND	430,070	430,070
UBS Group AG	[2025-06-30]	DFND	400,401	400,401
Two Sigma Investments LP	[2025-06-30]	SOLE	365,034	365,034
JPMorgan Chase & Co	[2025-06-30]	DFND	287,743	287,743
Citadel Advisors LLC	[2025-06-30]	DFND	218,987	218,987
Bank of America Corp /DE/	[2025-06-30]	DFND	0	217,967
Two Sigma Advisers LP	[2025-06-30]	SOLE	205,900	214,400
Jane Street Group LLC	[2025-06-30]	DFND	213,396	213,396
State Street Corp	[2025-06-30]	DFND	200,513	200,513
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	172,512
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	153,700	153,700
Troluce Capital Advisors LLC	[2025-06-30]	SOLE	150,000	150,000
Susquehanna International Group LLP	[2025-06-30]	OTR	144,372	144,372
Brown Brothers Harriman & Co	[2025-06-30]	SOLE	143,051	143,051
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