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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2025-06-30]	SOLE	378,346	378,346
BVF Inc/IL	[2025-06-30]	DFND	0	339,549
Millennium Management LLC	[2025-06-30]	SOLE	233,714	233,714
Vivo Capital LLC	[2025-06-30]	SOLE	208,333	208,333
Morgan Stanley	[2025-06-30]	DFND	174,750	178,010
Integral Health Asset Management LLC	[2025-06-30]	SOLE	167,000	167,000
Janus Henderson Group PLC	[2025-06-30]	DFND	0	166,666
Adar1 Capital Management LLC	[2025-06-30]	SOLE	155,557	155,557
VR Adviser LLC	[2025-06-30]	SOLE	98,564	98,564
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	83,333	83,333
Velan Capital Investment Management LP	[2025-06-30]	SOLE	83,333	83,333
Vestal Point Capital LP	[2025-06-30]	SOLE	53,439	53,439
Geode Capital Management LLC	[2025-06-30]	DFND	34,236	34,236
Vanguard Group Inc	[2025-06-30]	SOLE	0	22,287
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	15,930	15,930
Citadel Advisors LLC	[2025-06-30]	DFND	10,345	10,345
Raymond James Financial Inc	[2025-06-30]	DFND	0	1,503
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	1,249	1,249
BlackRock, Inc.	[2025-06-30]	SOLE	300	300
Bank of America Corp /DE/	[2025-06-30]	DFND	0	249
UBS Group AG	[2025-06-30]	DFND	14	14
Barclays PLC	[2025-06-30]	SOLE	11	11
Union Bancaire Privee, UBP SA	[2025-06-30]	DFND	1	1
Allworth Financial LP	[2025-06-30]	SOLE	0	1
Physician Wealth Advisors Inc	[2025-06-30]	SOLE	0	1
Jones Financial Companies LLLP	[2025-06-30]	SOLE	1	1
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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