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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	2,003,939	2,003,939
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,992,519	1,992,519
Bleichroeder LP	[2025-06-30]	SOLE	426,621	426,621
Rock Springs Capital Management LP	[2025-06-30]	SOLE	316,460	316,460
Geode Capital Management LLC	[2025-06-30]	DFND	165,394	165,394
Values First Advisors Inc	[2025-06-30]	SOLE	0	99,211
BlackRock, Inc.	[2025-06-30]	SOLE	91,548	91,548
Vanguard Group Inc	[2025-06-30]	SOLE	0	81,358
Renaissance Technologies LLC	[2025-06-30]	SOLE	22,526	22,526
State Street Corp	[2025-06-30]	DFND	22,182	22,182
XTX Topco Ltd	[2025-06-30]	DFND	13,723	13,723
Two Sigma Securities LLC	[2025-06-30]	SOLE	11,171	11,171
Northern Trust Corp	[2025-06-30]	DFND	10,891	10,891
Onyx Bridge Wealth Group LLC	[2025-06-30]	SOLE	0	10,300
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	4,834	4,834
MAI Capital Management	[2025-06-30]	SOLE	0	3,504
GPS Wealth Strategies Group LLC	[2025-06-30]	SOLE	0	2,313
Sterling Capital Management LLC	[2025-06-30]	SOLE	0	2,000
Newedge Advisors LLC	[2025-06-30]	SOLE	0	500
Wells Fargo & Company/MN	[2025-06-30]	DFND	0	483
Osaic Holdings Inc	[2025-06-30]	DFND	0	313
SBI Securities Co., Ltd.	[2025-06-30]	DFND	253	253
Bank of America Corp /DE/	[2025-06-30]	DFND	0	193
Raymond James Financial Inc	[2025-06-30]	DFND	0	145
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	136
Global Retirement Partners LLC	[2025-06-30]	SOLE	0	73
UBS Group AG	[2025-06-30]	DFND	0	22
Group One Trading LLC	[2025-06-30]	SOLE	15	15
CWM LLC	[2025-06-30]	SOLE	0	12
Morgan Stanley	[2025-06-30]	DFND	0	10
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