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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2025-06-30]	SOLE	4,543,895	4,543,895
Toronto Dominion Bank	[2025-06-30]	DFND	0	3,190,510
Morgan Stanley	[2025-06-30]	DFND	2,453,223	2,478,470
BlackRock, Inc.	[2025-06-30]	SOLE	2,342,698	2,405,241
Jefferies Financial Group Inc.	[2025-06-30]	DFND	2,229,652	2,229,652
Soleus Capital Management LP	[2025-06-30]	SOLE	2,185,000	2,185,000
SilverArc Capital Management LLC	[2025-06-30]	SOLE	2,022,482	2,022,482
Susquehanna International Group LLP	[2025-06-30]	OTR	484,823	1,288,223
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	1,259,749	1,259,749
Menora Mivtachim Holdings Ltd	[2025-06-30]	DFND	1,152,531	1,152,531
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,006,703	1,006,703
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,000,000
Citadel Advisors LLC	[2025-06-30]	DFND	994,496	994,496
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	830,000	830,000
State Street Corp	[2025-06-30]	DFND	767,508	807,638
Kynam Capital Management LP	[2025-06-30]	SOLE	656,573	656,573
Millennium Management LLC	[2025-06-30]	SOLE	594,031	638,931
Boxer Capital Management LLC	[2025-06-30]	SOLE	0	575,000
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	542,366	542,366
Wildcat Capital Management LLC	[2025-06-30]	SOLE	495,606	495,606
OrbiMed Advisors LLC	[2025-06-30]	SOLE	0	478,400
Geode Capital Management LLC	[2025-06-30]	DFND	470,726	470,726
JPMorgan Chase & Co	[2025-06-30]	DFND	372,576	390,364
Citigroup Inc	[2025-06-30]	DFND	384,891	384,891
DAFNA Capital Management LLC	[2025-06-30]	SOLE	349,515	349,515
Walleye Capital LLC	[2025-06-30]	SOLE	346,162	346,162
Jane Street Group LLC	[2025-06-30]	DFND	255,980	344,680
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	341,856	341,856
Atom Investors LP	[2025-06-30]	SOLE	317,596	317,596
UBS Group AG	[2025-06-30]	DFND	308,307	308,527
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