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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2025-06-30]	SOLE	0	6,348,690
MPM BioImpact LLC	[2025-06-30]	SOLE	4,911,948	4,911,948
Millennium Management LLC	[2025-06-30]	SOLE	2,621,493	2,621,493
UBS Group AG	[2025-06-30]	DFND	1,652,591	1,654,591
BlackRock, Inc.	[2025-06-30]	SOLE	1,631,998	1,640,337
Geode Capital Management LLC	[2025-06-30]	DFND	1,606,335	1,606,335
Ikarian Capital LLC	[2025-06-30]	SOLE	1,425,239	1,425,239
Oppenheimer & Co Inc	[2025-06-30]	SOLE	1,313,021	1,313,021
Susquehanna International Group LLP	[2025-06-30]	OTR	652,165	1,085,065
Deutsche Bank AG	[2025-06-30]	DFND	0	1,036,856
Jane Street Group LLC	[2025-06-30]	DFND	1,016,941	1,016,941
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,000,000	1,000,000
Citadel Advisors LLC	[2025-06-30]	DFND	927,528	927,528
Goldman Sachs Group Inc	[2025-06-30]	DFND	678,210	678,210
Envestnet Asset Management Inc	[2025-06-30]	SOLE	619,661	619,661
State Street Corp	[2025-06-30]	DFND	550,069	550,069
180 Wealth Advisors LLC	[2025-06-30]	SOLE	351,007	458,887
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	405,292
Blair William & Co/IL	[2025-06-30]	SOLE	380,000	380,000
Marshall Wace LLP	[2025-06-30]	OTR	0	379,840
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	361,399
Atria Investments Inc	[2025-06-30]	SOLE	0	282,281
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	260,793	260,793
Northern Trust Corp	[2025-06-30]	DFND	255,574	255,574
Morgan Stanley	[2025-06-30]	DFND	95,851	246,161
Sender Co & Partners, Inc.	[2025-06-30]	SOLE	238,231	238,231
Virtu Financial LLC	[2025-06-30]	DFND	207,640	207,640
Raymond James Financial Inc	[2025-06-30]	DFND	0	206,405
Quantinno Capital Management LP	[2025-06-30]	SOLE	200,000	200,000
Price T Rowe Associates Inc /MD/	[2025-06-30]	DFND	190,115	190,115
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