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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Alphabet Inc.	[2023-03-31]	DFND	0.0	10,549,086.0
FMR LLC	[2023-03-31]	DFND	6,741,675.0	6,826,817.0
ARK Investment Management LLC	[2023-03-31]	SOLE	4,385,803.0	4,482,091.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,810,569.0
BlackRock Inc.	[2023-03-31]	SOLE	3,466,777.0	3,546,485.0
State Street Corp	[2023-03-31]	DFND	3,263,689.0	3,349,777.0
Federated Hermes Inc	[2023-03-31]	DFND	2,402,640.0	2,402,640.0
Casdin Capital LLC	[2023-03-31]	SOLE	2,120,571.0	2,120,571.0
Arch Venture Management LLC	[2023-03-31]	SOLE	0.0	2,008,809.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	731,860.0	2,006,127.0
JPMorgan Chase & Co	[2023-03-31]	DFND	1,701,464.0	1,908,364.0
Nikko Asset Management Americas Inc	[2023-03-31]	SOLE	1,193,396.0	1,597,994.0
Sumitomo Mitsui Trust Holdings, Inc.	[2023-03-31]	DFND	1,597,994.0	1,597,994.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	1,416,530.0	1,416,530.0
Avidity Partners Management LP	[2023-03-31]	SOLE	1,351,700.0	1,351,700.0
Novo Holdings A/S	[2023-03-31]	SOLE	1,200,000.0	1,200,000.0
Redmile Group LLC	[2023-03-31]	SOLE	1,120,679.0	1,120,679.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	933,167.0
Geode Capital Management LLC	[2023-03-31]	DFND	885,771.0	885,771.0
Bioimpact Capital LLC	[2023-03-31]	SOLE	803,501.0	803,501.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	650,000.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	558,837.0	558,837.0
Citigroup Inc	[2023-03-31]	DFND	494,019.0	494,019.0
Citadel Advisors LLC	[2023-03-31]	DFND	434,662.0	434,662.0
Northern Trust Corp	[2023-03-31]	DFND	18,317.0	403,025.0
Woodline Partners LP	[2023-03-31]	SOLE	386,466.0	386,466.0
Bank of America Corp /DE/	[2023-03-31]	DFND	9,336.0	384,706.0
Cormorant Asset Management LP	[2023-03-31]	DFND	350,000.0	350,000.0
Hood River Capital Management LLC	[2023-03-31]	SOLE	319,314.0	344,776.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	322,300.0	322,300.0
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