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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Samsara Biocapital LLC	[2025-06-30]	SOLE	206,784	206,784
FMR LLC	[2025-06-30]	DFND	178,200	178,200
Baker Bros Advisors LP	[2025-06-30]	SOLE	97,314	97,314
Vanguard Group Inc	[2025-06-30]	SOLE	0	42,937
Northern Trust Corp	[2025-06-30]	DFND	15,287	15,287
Millennium Management LLC	[2025-06-30]	SOLE	15,042	15,042
Geode Capital Management LLC	[2025-06-30]	DFND	12,866	12,866
Connective Capital Management LLC	[2025-06-30]	SOLE	9,712	9,712
BlackRock, Inc.	[2025-06-30]	SOLE	4,827	4,827
UBS Group AG	[2025-06-30]	DFND	2,847	2,847
Morgan Stanley	[2025-06-30]	DFND	0	746
Vanguard Group Inc	[2025-06-30]	DFND	0	238
Osaic Holdings Inc	[2025-06-30]	DFND	0	150
Activest Wealth Management	[2025-06-30]	SOLE	0	50
Corecap Advisors LLC	[2025-06-30]	SOLE	45	45
Parallel Advisors LLC	[2025-06-30]	SOLE	0	38
Sunbelt Securities Inc	[2025-06-30]	SOLE	15	15
Bank of America Corp /DE/	[2025-06-30]	DFND	0	12
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	9
SBI Securities Co., Ltd.	[2025-06-30]	DFND	2	2
Raymond James Financial Inc	[2025-06-30]	DFND	0	1
Strategic Wealth Partners Ltd	[2025-06-30]	SOLE	1	1
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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