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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Casdin Capital LLC	[2025-06-30]	SOLE	3,507,164	3,507,164
Corvex Management LP	[2025-06-30]	SOLE	3,058,629	3,058,629
Pentwater Capital Management LP	[2025-06-30]	SOLE	2,270,000	2,270,000
William Blair Investment Management LLC	[2025-06-30]	SOLE	1,491,038	1,631,402
BlackRock, Inc.	[2025-06-30]	SOLE	1,400,786	1,434,634
Susquehanna International Group LLP	[2025-06-30]	OTR	24,906	1,392,406
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,135,398
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,044,413	1,049,441
UBS Group AG	[2025-06-30]	DFND	1,006,051	1,010,720
Oracle Investment Management Inc	[2025-06-30]	SOLE	922,454	922,454
Summit Partners Public Asset Management LLC	[2025-06-30]	SOLE	771,333	867,265
Jane Street Group LLC	[2025-06-30]	DFND	437,100	840,800
Fred Alger Management LLC	[2025-06-30]	SOLE	820,523	820,523
Westfield Capital Management Co LP	[2025-06-30]	SOLE	525,440	589,188
Zweig-Dimenna Associates LLC	[2025-06-30]	SOLE	586,100	586,100
Invesco Ltd.	[2025-06-30]	DFND	0	554,419
Morgan Stanley	[2025-06-30]	DFND	445,667	487,070
Geode Capital Management LLC	[2025-06-30]	DFND	484,714	484,714
Citadel Advisors LLC	[2025-06-30]	DFND	422,927	422,927
Lord Abbett & Co LLC	[2025-06-30]	SOLE	372,284	420,526
State Street Corp	[2025-06-30]	DFND	361,892	415,996
Raymond James Financial Inc	[2025-06-30]	DFND	130,443	413,223
Wellington Management Group LLP	[2025-06-30]	DFND	0	406,573
AllianceBernstein LP	[2025-06-30]	DFND	374,493	386,758
Jennison Associates LLC	[2025-06-30]	DFND	339,920	339,920
Franklin Resources Inc	[2025-06-30]	DFND	337,323	337,427
Farallon Capital Management LLC	[2025-06-30]	OTR	326,677	326,677
Macquarie Group Ltd	[2025-06-30]	SOLE	317,871	317,871
Science & Technology Partners LP	[2025-06-30]	SOLE	317,276	317,276
Driehaus Capital Management LLC	[2025-06-30]	SOLE	234,806	303,455
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