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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Gilead Sciences Inc	[2025-06-30]	SOLE	9,105,451	9,105,451
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	4,566,817	4,566,817
Merck & Co., Inc.	[2025-06-30]	DFND	0	1,483,758
Takeda Pharmaceutical Co Ltd	[2025-06-30]	DFND	1,475,121	1,475,121
Morgan Stanley	[2025-06-30]	DFND	0	1,444,326
Ghisallo Capital Management LLC	[2025-06-30]	SOLE	1,333,000	1,333,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,148,079
AJU IB Investment Co., Ltd.	[2025-06-30]	SOLE	667,742	667,742
FMR LLC	[2025-06-30]	DFND	511,820	511,820
Geode Capital Management LLC	[2025-06-30]	DFND	369,660	369,660
Trustees of Columbia University in the City of New York	[2025-06-30]	SOLE	249,635	249,635
UBS Group AG	[2025-06-30]	DFND	239,969	239,969
Squarepoint Ops LLC	[2025-06-30]	DFND	0	235,456
Balyasny Asset Management LP	[2025-06-30]	SOLE	198,859	198,859
Renaissance Technologies LLC	[2025-06-30]	SOLE	164,200	164,200
Avantax Planning Partners Inc	[2025-06-30]	SOLE	0	142,338
Two Sigma Investments LP	[2025-06-30]	SOLE	78,032	78,032
Northern Trust Corp	[2025-06-30]	DFND	66,609	66,609
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	56,081	56,081
State Street Corp	[2025-06-30]	DFND	43,390	43,390
XTX Topco Ltd	[2025-06-30]	DFND	34,721	34,721
LPL Financial LLC	[2025-06-30]	SOLE	0	31,000
Aptus Capital Advisors LLC	[2025-06-30]	SOLE	25,000	25,000
Mariner LLC	[2025-06-30]	SOLE	0	25,000
Raymond James Financial Inc	[2025-06-30]	DFND	0	18,761
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	15,412	15,412
Dunhill Financial LLC	[2025-06-30]	SOLE	10,274	10,274
Investors Asset Management of Georgia Inc /GA/ /ADV	[2025-06-30]	SOLE	0	10,000
Pinnacle Financial Group, LLC / IL	[2025-06-30]	SOLE	0	10,000
Federation des caisses Desjardins du Quebec	[2025-06-30]	DFND	3,300	3,300
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