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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	11,629,170	11,855,254
PRIMECAP Management Co/CA/	[2025-06-30]	SOLE	10,527,322	10,527,322
Vanguard Group Inc	[2025-06-30]	SOLE	0	8,483,928
EcoR1 Capital LLC	[2025-06-30]	SOLE	6,144,767	6,144,767
State Street Corp	[2025-06-30]	DFND	3,644,765	3,817,610
BVF Inc/IL	[2025-06-30]	DFND	0	2,740,141
TCG Crossover Management LLC	[2025-06-30]	SOLE	2,452,138	2,452,138
RTW Investments LP	[2025-06-30]	SOLE	2,402,883	2,402,883
Geode Capital Management LLC	[2025-06-30]	DFND	1,703,664	1,703,664
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,592,143	1,682,094
Braidwell LP	[2025-06-30]	SOLE	1,655,690	1,655,690
Royal Bank of Canada	[2025-06-30]	DFND	1,306,930	1,306,930
Logos Global Management LP	[2025-06-30]	SOLE	1,250,000	1,250,000
Morgan Stanley	[2025-06-30]	DFND	972,480	1,025,398
Bank of America Corp /DE/	[2025-06-30]	DFND	40,238	938,993
Woodline Partners LP	[2025-06-30]	SOLE	843,296	843,296
Nantahala Capital Management LLC	[2025-06-30]	SOLE	820,103	820,103
UBS Group AG	[2025-06-30]	DFND	774,125	776,196
Johnson & Johnson	[2025-06-30]	DFND	0	748,062
Goldman Sachs Group Inc	[2025-06-30]	DFND	716,097	716,392
Northern Trust Corp	[2025-06-30]	DFND	675,879	677,884
Baker Bros Advisors LP	[2025-06-30]	SOLE	670,431	670,431
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	598,979	599,039
Two Sigma Advisers LP	[2025-06-30]	SOLE	552,200	579,300
Aberdeen Group plc	[2025-06-30]	DFND	558,810	558,810
Deep Track Capital LP	[2025-06-30]	SOLE	549,439	549,439
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	361,124	521,667
PanAgora Asset Management Inc	[2025-06-30]	SOLE	228,709	488,892
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	485,000	485,000
Bank of New York Mellon Corp	[2025-06-30]	DFND	435,224	478,678
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