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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	6,197,423	6,197,423
Capital World Investors	[2025-06-30]	DFND	6,036,185	6,036,185
RTW Investments LP	[2025-06-30]	SOLE	5,536,876	5,536,876
Clearbridge Investments LLC	[2025-06-30]	SOLE	3,932,762	4,011,956
Janus Henderson Group PLC	[2025-06-30]	DFND	0	2,197,860
BAMCO Inc /NY/	[2025-06-30]	DFND	0	1,587,814
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,376,963
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	1,308,138	1,308,138
Woodline Partners LP	[2025-06-30]	SOLE	1,201,016	1,201,016
Allianz Asset Management GmbH	[2025-06-30]	DFND	932,000	932,000
Rock Springs Capital Management LP	[2025-06-30]	SOLE	871,392	871,392
Adar1 Capital Management LLC	[2025-06-30]	SOLE	850,437	850,437
MPM BioImpact LLC	[2025-06-30]	SOLE	745,060	745,060
Jennison Associates LLC	[2025-06-30]	DFND	337,168	560,734
C WorldWide Group Holding A/S	[2025-06-30]	DFND	510,000	510,000
BlackRock, Inc.	[2025-06-30]	SOLE	454,736	455,287
Citadel Advisors LLC	[2025-06-30]	DFND	420,713	420,713
B Group, Inc.	[2025-06-30]	SOLE	400,000	400,000
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	378,160	387,362
XY Capital Ltd	[2025-06-30]	SOLE	362,627	362,627
Morgan Stanley	[2025-06-30]	DFND	283,160	289,101
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	279,661	279,661
NAN FUNG TRINITY (HK) Ltd	[2025-06-30]	SOLE	269,975	269,975
Point72 Asset Management LP	[2025-06-30]	DFND	0	252,400
Stempoint Capital LP	[2025-06-30]	SOLE	222,039	250,438
UBS Group AG	[2025-06-30]	DFND	241,585	241,650
Envestnet Asset Management Inc	[2025-06-30]	SOLE	239,247	239,247
Candriam S.C.A.	[2025-06-30]	SOLE	238,897	238,897
Renaissance Technologies LLC	[2025-06-30]	SOLE	232,900	232,900
OrbiMed Advisors LLC	[2025-06-30]	SOLE	0	231,000
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