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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	8,800,000	8,800,000
Perceptive Advisors LLC	[2025-06-30]	SOLE	7,902,365	7,902,365
TCG Crossover Management LLC	[2025-06-30]	SOLE	5,943,812	5,943,812
BlackRock, Inc.	[2025-06-30]	SOLE	5,369,247	5,510,189
Point72 Asset Management LP	[2025-06-30]	DFND	0	4,536,266
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,409,744
Saturn V Capital Management LP	[2025-06-30]	SOLE	3,260,570	3,260,570
FMR LLC	[2025-06-30]	DFND	3,031,342	3,048,019
Nantahala Capital Management LLC	[2025-06-30]	SOLE	2,934,405	2,934,405
683 Capital Management LLC	[2025-06-30]	DFND	2,160,000	2,160,000
Almitas Capital LLC	[2025-06-30]	SOLE	2,122,597	2,122,597
Great Point Partners LLC	[2025-06-30]	SOLE	0	2,000,000
Geode Capital Management LLC	[2025-06-30]	DFND	1,692,413	1,692,413
Millennium Management LLC	[2025-06-30]	SOLE	1,512,058	1,512,058
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,288,270	1,297,982
Citadel Advisors LLC	[2025-06-30]	DFND	1,287,527	1,287,527
Driehaus Capital Management LLC	[2025-06-30]	SOLE	1,264,997	1,264,997
UBS Group AG	[2025-06-30]	DFND	1,250,739	1,253,344
Boxer Capital Management LLC	[2025-06-30]	SOLE	0	1,225,000
Adar1 Capital Management LLC	[2025-06-30]	SOLE	1,205,101	1,205,101
Woodline Partners LP	[2025-06-30]	SOLE	1,200,290	1,200,290
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	1,154,485	1,154,485
State Street Corp	[2025-06-30]	DFND	912,523	1,008,909
Northern Trust Corp	[2025-06-30]	DFND	809,547	809,547
Aberdeen Group plc	[2025-06-30]	DFND	738,657	738,657
PFM Health Sciences LP	[2025-06-30]	DFND	0	732,256
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	650,000	650,000
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	646,443	646,443
Deutsche Bank AG	[2025-06-30]	DFND	1,123	616,919
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	588,411	588,411
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