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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
EcoR1 Capital LLC	[2025-06-30]	SOLE	7,880,094	7,880,094
First Light Asset Management LLC	[2025-06-30]	SOLE	3,539,593	3,539,593
Point72 Asset Management LP	[2025-06-30]	DFND	0	2,474,874
Morgan Stanley	[2025-06-30]	DFND	1,862,553	1,869,840
BlackRock, Inc.	[2025-06-30]	SOLE	1,753,214	1,786,934
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,502,076
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,330,879
UBS Group AG	[2025-06-30]	DFND	1,271,601	1,272,499
Bank of America Corp /DE/	[2025-06-30]	DFND	7,131	1,076,799
Citigroup Inc	[2025-06-30]	DFND	1,046,488	1,046,488
Sofinnova Investments Inc	[2025-06-30]	SOLE	1,032,362	1,032,362
Sanofi	[2025-06-30]	SOLE	821,917	821,917
State Street Corp	[2025-06-30]	DFND	761,243	821,031
Palo Alto Investors LP	[2025-06-30]	SOLE	812,821	812,821
Woodline Partners LP	[2025-06-30]	SOLE	501,023	501,023
683 Capital Management LLC	[2025-06-30]	DFND	500,000	500,000
Victory Capital Management Inc	[2025-06-30]	SOLE	497,705	497,705
Geode Capital Management LLC	[2025-06-30]	DFND	463,358	463,358
Susquehanna International Group LLP	[2025-06-30]	OTR	189,327	426,527
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	319,348	368,447
Franklin Resources Inc	[2025-06-30]	DFND	354,508	354,508
Nuveen, LLC	[2025-06-30]	DFND	322,515	323,534
Soleus Capital Management LP	[2025-06-30]	SOLE	321,040	321,040
Two Sigma Advisers LP	[2025-06-30]	SOLE	274,600	290,400
Goldman Sachs Group Inc	[2025-06-30]	DFND	279,580	279,835
Renaissance Technologies LLC	[2025-06-30]	SOLE	263,086	263,086
JPMorgan Chase & Co	[2025-06-30]	DFND	236,744	247,625
Two Sigma Investments LP	[2025-06-30]	SOLE	231,369	231,369
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	215,454	215,454
Millennium Management LLC	[2025-06-30]	SOLE	203,542	203,542
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