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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vestal Point Capital LP	[2025-06-30]	SOLE	5,600,000	5,600,000
NEA Management Company LLC	[2025-06-30]	DFND	4,448,757	4,448,757
Bellevue Group AG	[2025-06-30]	DFND	2,733,547	2,733,547
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,087,365
Tang Capital Management LLC	[2025-06-30]	OTR	0	2,070,209
BlackRock, Inc.	[2025-06-30]	SOLE	1,089,479	1,090,863
Siren, L.L.C.	[2025-06-30]	DFND	1,046,517	1,046,517
Millennium Management LLC	[2025-06-30]	SOLE	944,853	944,853
Marshall Wace LLP	[2025-06-30]	OTR	0	737,875
AWM Investment Company Inc	[2025-06-30]	SOLE	500,000	500,000
Geode Capital Management LLC	[2025-06-30]	DFND	495,343	495,343
DAFNA Capital Management LLC	[2025-06-30]	SOLE	471,000	471,000
FMR LLC	[2025-06-30]	DFND	400,833	413,886
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	352,243	393,663
Goldman Sachs Group Inc	[2025-06-30]	DFND	350,644	350,644
J Goldman & Co LP	[2025-06-30]	SOLE	323,999	323,999
UBS Group AG	[2025-06-30]	DFND	313,695	313,700
GSA Capital Partners LLP	[2025-06-30]	SOLE	240,011	240,011
Stifel Financial Corp	[2025-06-30]	DFND	219,550	219,945
State Street Corp	[2025-06-30]	DFND	213,513	213,513
Jane Street Group LLC	[2025-06-30]	DFND	208,477	208,477
AQR Capital Management LLC	[2025-06-30]	DFND	205,870	205,870
Citadel Advisors LLC	[2025-06-30]	DFND	185,272	185,272
XTX Topco Ltd	[2025-06-30]	DFND	179,234	179,234
Renaissance Technologies LLC	[2025-06-30]	SOLE	167,100	167,100
TD Asset Management Inc	[2025-06-30]	SOLE	165,678	165,678
Northern Trust Corp	[2025-06-30]	DFND	151,421	151,421
Arrowstreet Capital Limited Partnership	[2025-06-30]	DFND	138,144	138,144
Bank of New York Mellon Corp	[2025-06-30]	DFND	125,672	125,672
Susquehanna International Group LLP	[2025-06-30]	OTR	120,073	120,073
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