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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Casdin Capital LLC	[2023-03-31]	SOLE	7,571,535.0	7,571,535.0
BlackRock Inc.	[2023-03-31]	SOLE	5,359,369.0	5,427,569.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,435,798.0
Fred Alger Management LLC	[2023-03-31]	SOLE	1,925,215.0	1,925,215.0
Park West Asset Management LLC	[2023-03-31]	SOLE	1,453,129.0	1,453,129.0
State Street Corp	[2023-03-31]	DFND	1,030,299.0	1,096,227.0
Palisade Capital Management LP	[2023-03-31]	SOLE	759,524.0	1,079,814.0
Geneva Capital Management LLC	[2023-03-31]	SOLE	975,083.0	998,814.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	964,087.0
Granahan Investment Management LLC	[2023-03-31]	SOLE	689,680.0	851,197.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	807,640.0
Jennison Associates LLC	[2023-03-31]	DFND	784,396.0	784,396.0
Geode Capital Management LLC	[2023-03-31]	DFND	665,316.0	665,316.0
Gagnon Securities LLC	[2023-03-31]	SOLE	0.0	649,918.0
Geneva Capital Management LLC	[2023-03-31]	OTR	559,879.0	559,879.0
Millennium Management LLC	[2023-03-31]	SOLE	479,406.0	479,406.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	425,199.0	453,327.0
Morgan Stanley	[2023-03-31]	DFND	365,487.0	417,263.0
JPMorgan Chase & Co	[2023-03-31]	DFND	362,446.0	405,268.0
BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp	[2023-03-31]	SOLE	400,000.0	400,000.0
Northern Trust Corp	[2023-03-31]	DFND	31,299.0	377,715.0
Peregrine Capital Management LLC	[2023-03-31]	SOLE	98,668.0	365,874.0
New York State Common Retirement Fund	[2023-03-31]	SOLE	362,462.0	362,462.0
Gagnon Advisors LLC	[2023-03-31]	SOLE	0.0	360,758.0
RMB Capital Management LLC	[2023-03-31]	SOLE	346,462.0	346,462.0
Zweig-Dimenna Associates LLC	[2023-03-31]	SOLE	332,000.0	332,000.0
Ranger Investment Management LP	[2023-03-31]	SOLE	234,502.0	330,825.0
Bank of America Corp /DE/	[2023-03-31]	DFND	225,986.0	315,302.0
Stephens Investment Management Group LLC	[2023-03-31]	DFND	0.0	311,878.0
FMR LLC	[2023-03-31]	DFND	294,384.0	295,592.0
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