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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Suvretta Capital Management LLC	[2025-06-30]	SOLE	9,876,506	9,876,506
Janus Henderson Group PLC	[2025-06-30]	DFND	0	2,902,794
Franklin Resources Inc	[2025-06-30]	DFND	2,701,443	2,701,443
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,972,524	1,972,524
Vanguard Group Inc	[2025-06-30]	SOLE	0	946,412
Nantahala Capital Management LLC	[2025-06-30]	SOLE	838,095	838,095
BlackRock, Inc.	[2025-06-30]	SOLE	708,789	718,690
Infinitum Asset Management LLC	[2025-06-30]	SOLE	500,000	500,000
Geode Capital Management LLC	[2025-06-30]	DFND	415,211	415,211
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	260,417	260,417
SilverArc Capital Management LLC	[2025-06-30]	SOLE	253,234	253,234
State Street Corp	[2025-06-30]	DFND	146,725	161,073
AWM Investment Company Inc	[2025-06-30]	SOLE	137,977	137,977
Northern Trust Corp	[2025-06-30]	DFND	124,108	124,108
Ameriprise Financial Inc	[2025-06-30]	DFND	0	109,925
ExodusPoint Capital Management LP	[2025-06-30]	SOLE	76,379	76,379
Simplify Asset Management Inc	[2025-06-30]	SOLE	69,173	69,173
MYDA Advisors LLC	[2025-06-30]	SOLE	62,116	62,116
Lion Point Capital LP	[2025-06-30]	SOLE	62,000	62,000
Longaeva Partners L.P.	[2025-06-30]	OTR	0	51,997
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	45,274	45,274
Marshall Wace LLP	[2025-06-30]	OTR	0	43,003
Informed Momentum Co LLC	[2025-06-30]	SOLE	37,809	37,809
Morgan Stanley	[2025-06-30]	DFND	34,322	34,322
Bank of New York Mellon Corp	[2025-06-30]	DFND	31,391	31,951
Barclays PLC	[2025-06-30]	SOLE	26,940	26,940
Vanguard Group Inc	[2025-06-30]	DFND	0	22,754
Goldman Sachs Group Inc	[2025-06-30]	DFND	20,994	20,994
RhumbLine Advisers	[2025-06-30]	SOLE	6,346	20,858
Nuveen, LLC	[2025-06-30]	DFND	18,779	18,779
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