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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	9,677,125	9,677,125
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	8,829,758	8,829,758
Jennison Associates LLC	[2025-06-30]	DFND	6,020,167	6,020,167
Cormorant Asset Management LP	[2025-06-30]	DFND	5,000,000	5,000,000
Alyeska Investment Group LP	[2025-06-30]	SOLE	4,800,000	4,800,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,429,146
Heights Capital Management Inc	[2025-06-30]	OTR	3,144,106	3,144,106
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	2,172,339	2,172,339
Jefferies Financial Group Inc.	[2025-06-30]	DFND	1,997,208	1,997,208
Burkehill Global Management LP	[2025-06-30]	SOLE	1,900,000	1,900,000
Anson Funds Management LP	[2025-06-30]	DFND	1,822,830	1,822,830
Citadel Advisors LLC	[2025-06-30]	DFND	1,793,280	1,793,280
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	1,484,836	1,484,836
Morgan Stanley	[2025-06-30]	DFND	389,768	1,324,806
Woodline Partners LP	[2025-06-30]	SOLE	1,218,464	1,218,464
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	1,125,000
Superstring Capital Management LP	[2025-06-30]	SOLE	1,060,764	1,060,764
BlackRock, Inc.	[2025-06-30]	SOLE	968,622	970,601
Millennium Management LLC	[2025-06-30]	SOLE	855,330	855,330
Geode Capital Management LLC	[2025-06-30]	DFND	553,462	553,462
Cantor Fitzgerald L P	[2025-06-30]	DFND	0	532,500
Bank of America Corp /DE/	[2025-06-30]	DFND	0	498,243
UBS Group AG	[2025-06-30]	DFND	467,714	472,042
Susquehanna International Group LLP	[2025-06-30]	OTR	123,625	435,725
Two Sigma Advisers LP	[2025-06-30]	SOLE	388,400	413,600
Almitas Capital LLC	[2025-06-30]	SOLE	367,491	367,491
Goldman Sachs Group Inc	[2025-06-30]	DFND	353,307	353,307
Federated Hermes Inc	[2025-06-30]	DFND	344,540	344,540
Jane Street Group LLC	[2025-06-30]	DFND	238,325	317,625
Raiffeisen Bank International AG	[2025-06-30]	SOLE	300,000	300,000
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