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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock Inc.	[2023-03-31]	SOLE	7,482,488.0	7,600,482.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,053,355.0
Bain Capital Life Sciences Investors, LLC	[2023-03-31]	SOLE	2,204,449.0	2,204,449.0
Farallon Capital Management LLC	[2023-03-31]	OTR	1,995,370.0	1,995,370.0
State Street Corp	[2023-03-31]	DFND	1,805,522.0	1,902,942.0
Disciplined Growth Investors Inc /MN	[2023-03-31]	SOLE	1,732,375.0	1,732,375.0
Kingdon Capital Management LLC	[2023-03-31]	DFND	1,233,000.0	1,233,000.0
Chescapmanager LLC	[2023-03-31]	DFND	1,160,392.0	1,160,392.0
Geode Capital Management LLC	[2023-03-31]	DFND	892,319.0	892,319.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	801,160.0	873,534.0
Bank of America Corp /DE/	[2023-03-31]	DFND	8,489.0	760,850.0
Northern Trust Corp	[2023-03-31]	DFND	21,928.0	704,393.0
Pinnacle Associates Ltd	[2023-03-31]	SOLE	678,338.0	679,413.0
C WorldWide Group Holding A/S	[2023-03-31]	DFND	583,460.0	583,460.0
Citadel Advisors LLC	[2023-03-31]	DFND	560,571.0	560,571.0
Clearbridge Investments LLC	[2023-03-31]	SOLE	437,710.0	485,535.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	371,363.0	403,402.0
Morgan Stanley	[2023-03-31]	DFND	352,849.0	380,020.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	335,872.0	335,872.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	286,719.0	303,625.0
Principal Financial Group Inc	[2023-03-31]	DFND	280,872.0	280,872.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	244,181.0
ExodusPoint Capital Management LP	[2023-03-31]	SOLE	213,644.0	213,644.0
Jupiter Asset Management Ltd	[2023-03-31]	DFND	202,341.0	202,341.0
Royce & Associates LP	[2023-03-31]	SOLE	202,300.0	202,300.0
Squarepoint Ops LLC	[2023-03-31]	DFND	0.0	195,818.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	190,630.0
Federated Hermes Inc	[2023-03-31]	DFND	184,349.0	184,349.0
LPL Financial LLC	[2023-03-31]	SOLE	9,702.0	174,868.0
Two Sigma Investments LP	[2023-03-31]	SOLE	163,736.0	163,736.0
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