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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
ARK Investment Management LLC	[2023-03-31]	SOLE	6,799,439.0	6,799,439.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	5,038,866.0
State Street Corp	[2023-03-31]	DFND	4,761,955.0	4,878,036.0
BlackRock Inc.	[2023-03-31]	SOLE	4,278,063.0	4,364,634.0
Bellevue Group AG	[2023-03-31]	DFND	3,439,091.0	3,439,091.0
Armistice Capital LLC	[2023-03-31]	SOLE	3,136,000.0	3,136,000.0
Sumitomo Mitsui Trust Holdings, Inc.	[2023-03-31]	DFND	2,750,468.0	2,750,468.0
Nikko Asset Management Americas Inc	[2023-03-31]	SOLE	1,909,227.0	2,750,468.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	2,023,992.0	2,034,528.0
Gagnon Securities LLC	[2023-03-31]	SOLE	0.0	2,013,813.0
Millennium Management LLC	[2023-03-31]	SOLE	1,699,800.0	1,834,800.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	1,164,368.0	1,164,368.0
Morgan Stanley	[2023-03-31]	DFND	1,068,700.0	1,111,098.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	1,026,900.0	1,026,900.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,016,530.0	1,016,530.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	708,648.0	720,785.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	639,257.0
Voloridge Investment Management LLC	[2023-03-31]	SOLE	622,369.0	622,369.0
Gagnon Advisors LLC	[2023-03-31]	SOLE	0.0	526,088.0
First Eagle Investment Management LLC	[2023-03-31]	SOLE	523,367.0	523,367.0
Bank of America Corp /DE/	[2023-03-31]	DFND	27,530.0	510,603.0
Credit Suisse AG	[2023-03-31]	DFND	465,239.0	482,781.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	406,200.0	478,400.0
Northern Trust Corp	[2023-03-31]	DFND	28,880.0	471,708.0
Citadel Advisors LLC	[2023-03-31]	DFND	452,566.0	452,566.0
Royce & Associates LP	[2023-03-31]	SOLE	432,505.0	432,505.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	421,278.0	421,278.0
Rafferty Asset Management LLC	[2023-03-31]	SOLE	407,347.0	407,347.0
Cubist Systematic Strategies, LLC	[2023-03-31]	DFND	0.0	350,910.0
Citigroup Inc	[2023-03-31]	DFND	328,563.0	328,563.0
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