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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,786,576
BlackRock, Inc.	[2025-06-30]	SOLE	4,556,329	4,657,919
Invesco Ltd.	[2025-06-30]	DFND	0	2,543,419
BAMCO Inc /NY/	[2025-06-30]	DFND	0	2,435,657
State Street Corp	[2025-06-30]	DFND	2,074,473	2,180,145
ARK Investment Management LLC	[2025-06-30]	SOLE	2,100,157	2,100,157
Ophir Asset Management Pty Ltd	[2025-06-30]	SOLE	1,892,994	1,892,994
Hood River Capital Management LLC	[2025-06-30]	SOLE	1,713,346	1,765,981
Gagnon Securities LLC	[2025-06-30]	SOLE	0	1,548,912
Geode Capital Management LLC	[2025-06-30]	DFND	1,323,497	1,323,497
Sumitomo Mitsui Trust Group, Inc.	[2025-06-30]	DFND	1,236,928	1,236,928
Nikko Asset Management Americas Inc	[2025-06-30]	SOLE	997,116	1,235,591
Fred Alger Management LLC	[2025-06-30]	SOLE	1,233,759	1,233,759
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,155,698	1,155,698
Next Century Growth Investors LLC	[2025-06-30]	SOLE	1,061,279	1,125,454
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,070,525	1,118,922
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	836,368	1,092,401
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	1,082,308	1,082,308
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	842,881	887,522
Citadel Advisors LLC	[2025-06-30]	DFND	822,467	822,467
Royce & Associates LP	[2025-06-30]	SOLE	778,604	778,604
Bellevue Group AG	[2025-06-30]	DFND	752,371	752,371
Blue Water Life Science Advisors LP	[2025-06-30]	SOLE	724,014	724,014
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	719,207	719,207
Portolan Capital Management LLC	[2025-06-30]	SOLE	629,977	629,977
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	615,374	615,374
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	526,028	526,028
Macquarie Group Ltd	[2025-06-30]	SOLE	513,767	513,767
Chevy Chase Trust Holdings, LLC	[2025-06-30]	DFND	0	512,549
Northern Trust Corp	[2025-06-30]	DFND	483,411	484,474
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