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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
MPM BioImpact LLC	[2025-06-30]	SOLE	14,705,882	14,705,882
Avidity Partners Management LP	[2025-06-30]	SOLE	7,477,255	7,477,255
Deep Track Capital LP	[2025-06-30]	SOLE	7,419,355	7,419,355
Nextech Invest Ltd	[2025-06-30]	SOLE	7,419,355	7,419,355
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	7,407,906
Great Point Partners LLC	[2025-06-30]	SOLE	0	4,683,711
Franklin Resources Inc	[2025-06-30]	DFND	4,003,380	4,003,380
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,347,970
Blackstone Inc.	[2025-06-30]	OTR	0	2,440,330
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,935,484	1,935,484
Alyeska Investment Group LP	[2025-06-30]	SOLE	1,663,355	1,663,355
SIO Capital Management LLC	[2025-06-30]	SOLE	1,341,636	1,341,636
BlackRock, Inc.	[2025-06-30]	SOLE	848,970	848,970
Woodline Partners LP	[2025-06-30]	SOLE	680,188	680,188
Geode Capital Management LLC	[2025-06-30]	DFND	637,810	637,810
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	518,025	518,025
Renaissance Technologies LLC	[2025-06-30]	SOLE	363,930	363,930
Adar1 Capital Management LLC	[2025-06-30]	SOLE	351,094	351,094
Luminus Management LLC	[2025-06-30]	SOLE	328,222	328,222
State Street Corp	[2025-06-30]	DFND	152,607	152,607
Walleye Capital LLC	[2025-06-30]	SOLE	132,786	132,786
Hightower Advisors LLC	[2025-06-30]	SOLE	125,852	125,852
Northern Trust Corp	[2025-06-30]	DFND	113,565	113,565
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	106,779	106,779
Mill Creek Capital Advisors LLC	[2025-06-30]	SOLE	104,631	104,631
Velan Capital Investment Management LP	[2025-06-30]	SOLE	100,000	100,000
Clear Harbor Asset Management LLC	[2025-06-30]	SOLE	57,804	57,804
GTS Securities LLC	[2025-06-30]	DFND	44,176	44,176
Cerity Partners LLC	[2025-06-30]	SOLE	20,000	20,000
Caxton Corp	[2025-06-30]	SOLE	18,403	18,403
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