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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock Inc.	[2023-03-31]	SOLE	15,236,655.0	15,356,690.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	10,355,099.0	10,355,099.0
State Street Corp	[2023-03-31]	DFND	7,323,544.0	7,542,718.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	6,673,335.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	2,134,435.0	2,250,462.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,854,222.0	1,854,222.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	1,395,792.0	1,577,692.0
Morgan Stanley	[2023-03-31]	DFND	1,055,090.0	1,428,313.0
Jupiter Asset Management Ltd	[2023-03-31]	DFND	1,423,584.0	1,423,584.0
Northern Trust Corp	[2023-03-31]	DFND	68,290.0	1,389,547.0
Millennium Management LLC	[2023-03-31]	SOLE	1,355,095.0	1,355,095.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	1,219,175.0	1,219,175.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	1,087,094.0	1,218,994.0
Two Sigma Investments LP	[2023-03-31]	SOLE	1,184,425.0	1,184,425.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	1,160,522.0	1,179,422.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	1,093,998.0	1,136,737.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	1,134,848.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	1,090,100.0	1,090,100.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	252,358.0	994,558.0
Bank of America Corp /DE/	[2023-03-31]	DFND	78,130.0	985,880.0
LSV Asset Management	[2023-03-31]	SOLE	440,900.0	957,800.0
Deutsche Bank AG	[2023-03-31]	DFND	19,045.0	934,738.0
Man Group plc	[2023-03-31]	DFND	899,823.0	899,823.0
Parallax Volatility Advisers LP	[2023-03-31]	SOLE	816,085.0	816,085.0
American Century Companies Inc	[2023-03-31]	DFND	812,206.0	812,206.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	770,795.0	801,448.0
JPMorgan Chase & Co	[2023-03-31]	DFND	557,326.0	751,353.0
Prudential Financial Inc	[2023-03-31]	DFND	165,200.0	744,609.0
Royce & Associates LP	[2023-03-31]	SOLE	615,968.0	615,968.0
Principal Financial Group Inc	[2023-03-31]	DFND	613,499.0	613,499.0
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