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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
ARK Investment Management LLC	[2023-03-31]	SOLE	7,304,293.0	7,990,188.0
Capital International Investors	[2023-03-31]	DFND	6,023,638.0	6,023,638.0
Sumitomo Mitsui Trust Holdings, Inc.	[2023-03-31]	DFND	3,973,180.0	3,973,180.0
Nikko Asset Management Americas Inc	[2023-03-31]	SOLE	3,604,564.0	3,972,139.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	1,448,282.0	3,664,371.0
BlackRock Inc.	[2023-03-31]	SOLE	2,669,721.0	2,798,581.0
FMR LLC	[2023-03-31]	DFND	2,136,757.0	2,139,056.0
State Street Corp	[2023-03-31]	DFND	1,896,138.0	1,986,187.0
NEA Management Company LLC	[2023-03-31]	DFND	1,587,854.0	1,587,854.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,392,430.0
Loomis Sayles & Co L P	[2023-03-31]	DFND	1,052,895.0	1,156,810.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	223,949.0	1,081,903.0
Bellevue Group AG	[2023-03-31]	DFND	899,800.0	899,800.0
Credit Suisse AG	[2023-03-31]	DFND	827,208.0	847,273.0
Armistice Capital LLC	[2023-03-31]	SOLE	824,000.0	824,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	809,984.0	809,984.0
Susquehanna International Group LLP	[2023-03-31]	DFND	296,789.0	759,789.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	640,777.0	640,777.0
Citadel Advisors LLC	[2023-03-31]	DFND	621,239.0	621,239.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	585,508.0	594,682.0
JPMorgan Chase & Co	[2023-03-31]	DFND	480,551.0	575,953.0
Bank of America Corp /DE/	[2023-03-31]	DFND	16,525.0	517,706.0
Federated Hermes Inc	[2023-03-31]	DFND	508,758.0	508,758.0
Versant Venture Management LLC	[2023-03-31]	OTR	0.0	498,558.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	0.0	495,103.0
Morgan Stanley	[2023-03-31]	DFND	214,028.0	470,526.0
Barclays PLC	[2023-03-31]	SOLE	461,759.0	461,759.0
Walleye Trading LLC	[2023-03-31]	SOLE	450,300.0	450,300.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	293,853.0	308,454.0
Allspring Global Investments Holdings, LLC	[2023-03-31]	DFND	147,558.0	303,779.0
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