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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
ARK Investment Management LLC	[2025-06-30]	SOLE	9,521,127	10,182,590
BlackRock, Inc.	[2025-06-30]	SOLE	5,889,772	6,066,358
Capital International Investors	[2025-06-30]	DFND	5,593,747	5,593,747
State Street Corp	[2025-06-30]	DFND	2,998,246	3,270,596
UBS Group AG	[2025-06-30]	DFND	2,284,998	2,856,361
Orbis Allan Gray Ltd	[2025-06-30]	DFND	2,764,532	2,764,532
Sumitomo Mitsui Trust Group, Inc.	[2025-06-30]	DFND	2,414,838	2,414,838
Nikko Asset Management Americas Inc	[2025-06-30]	SOLE	2,223,784	2,414,271
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,143,596
Geode Capital Management LLC	[2025-06-30]	DFND	2,071,883	2,071,883
Susquehanna International Group LLP	[2025-06-30]	OTR	769,945	2,068,945
FMR LLC	[2025-06-30]	DFND	1,920,308	1,929,154
Bank of America Corp /DE/	[2025-06-30]	DFND	24,473	1,704,415
NEA Management Company LLC	[2025-06-30]	DFND	1,587,854	1,587,854
Two Sigma Investments LP	[2025-06-30]	SOLE	1,545,966	1,545,966
EcoR1 Capital LLC	[2025-06-30]	SOLE	1,389,276	1,389,276
Two Sigma Advisers LP	[2025-06-30]	SOLE	1,294,200	1,344,700
Citadel Advisors LLC	[2025-06-30]	DFND	1,288,078	1,288,078
SR One Capital Management LP	[2025-06-30]	SOLE	1,048,951	1,048,951
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	933,204	933,204
Loomis Sayles & Co L P	[2025-06-30]	DFND	787,660	856,887
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	809,469	818,955
Peak6 LLC	[2025-06-30]	DFND	786,400	786,400
Northern Trust Corp	[2025-06-30]	DFND	747,216	747,216
National Bank of Canada /FI/	[2025-06-30]	DFND	0	735,600
Bank of Montreal /Can/	[2025-06-30]	DFND	676,191	676,743
Morgan Stanley	[2025-06-30]	DFND	262,466	511,380
Versant Venture Management LLC	[2025-06-30]	OTR	0	498,558
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	SOLE	365,976	444,201
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	OTR	8,758	421,730
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