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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Johnson & Johnson	[2025-06-30]	DFND	0	1,979,173
Suvretta Capital Management LLC	[2025-06-30]	SOLE	1,720,000	1,720,000
Franklin Resources Inc	[2025-06-30]	DFND	1,698,825	1,698,825
FMR LLC	[2025-06-30]	DFND	841,738	843,150
Sectoral Asset Management Inc	[2025-06-30]	SOLE	800,787	800,787
Vanguard Group Inc	[2025-06-30]	SOLE	0	741,512
Perceptive Advisors LLC	[2025-06-30]	SOLE	699,486	699,486
HHLR Advisors Ltd	[2025-06-30]	OTR	0	669,337
Red Tree Management LLC	[2025-06-30]	SOLE	638,158	638,158
Samsara Biocapital LLC	[2025-06-30]	SOLE	588,816	588,816
Versant Venture Management LLC	[2025-06-30]	OTR	0	542,628
Point72 Asset Management LP	[2025-06-30]	DFND	0	388,639
Saturn V Capital Management LP	[2025-06-30]	SOLE	319,348	319,348
Baker Bros Advisors LP	[2025-06-30]	SOLE	312,500	312,500
Norges Bank	[2025-06-30]	SOLE	169,729	169,729
Adar1 Capital Management LLC	[2025-06-30]	SOLE	166,799	166,799
BlackRock, Inc.	[2025-06-30]	SOLE	165,446	165,446
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	164,124	164,124
Casdin Capital LLC	[2025-06-30]	SOLE	148,333	148,333
Millennium Management LLC	[2025-06-30]	SOLE	132,378	132,378
Morgan Stanley	[2025-06-30]	DFND	64,966	92,902
Squarepoint Ops LLC	[2025-06-30]	DFND	0	89,414
Monaco Asset Management SAM	[2025-06-30]	SOLE	75,000	75,000
Geode Capital Management LLC	[2025-06-30]	DFND	71,303	71,303
Two Sigma Investments LP	[2025-06-30]	SOLE	60,963	60,963
Goldman Sachs Group Inc	[2025-06-30]	DFND	60,922	60,922
Strategies Wealth Advisors LLC	[2025-06-30]	SOLE	0	50,000
Two Sigma Advisers LP	[2025-06-30]	SOLE	42,000	43,200
RBF Capital, LLC	[2025-06-30]	SOLE	40,000	40,000
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	35,156	35,156
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