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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	11,339,833	11,342,699
BlackRock, Inc.	[2025-06-30]	SOLE	9,208,022	9,830,431
Atlas Venture Life Science Advisors LLC	[2025-06-30]	SOLE	6,430,257	6,430,257
Vanguard Group Inc	[2025-06-30]	SOLE	0	6,069,588
Franklin Resources Inc	[2025-06-30]	DFND	4,097,625	4,097,625
Deerfield Management Company LP	[2025-06-30]	DFND	3,723,131	3,723,131
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	3,465,381	3,722,732
Alyeska Investment Group LP	[2025-06-30]	SOLE	3,012,187	3,012,187
Vestal Point Capital LP	[2025-06-30]	SOLE	3,000,000	3,000,000
State Street Corp	[2025-06-30]	DFND	2,571,188	2,689,686
Braidwell LP	[2025-06-30]	SOLE	2,181,598	2,181,598
Polar Capital Holdings Plc	[2025-06-30]	DFND	2,109,177	2,109,177
Geode Capital Management LLC	[2025-06-30]	DFND	1,712,429	1,712,429
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,691,126	1,691,286
Morgan Stanley	[2025-06-30]	DFND	1,344,959	1,353,148
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	1,296,700	1,296,700
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,192,804	1,266,561
Millennium Management LLC	[2025-06-30]	SOLE	1,207,802	1,207,802
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	1,003,279	1,043,030
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,000,540	1,000,540
Bank of America Corp /DE/	[2025-06-30]	DFND	9,190	965,423
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	944,202	944,202
DAFNA Capital Management LLC	[2025-06-30]	SOLE	879,163	879,163
EcoR1 Capital LLC	[2025-06-30]	SOLE	862,068	862,068
Citadel Advisors LLC	[2025-06-30]	DFND	746,744	746,744
Northern Trust Corp	[2025-06-30]	DFND	600,081	600,081
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	578,763	578,763
J Goldman & Co LP	[2025-06-30]	SOLE	557,480	557,480
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	500,000	500,000
Kennedy Capital Management LLC	[2025-06-30]	SOLE	453,520	453,520
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