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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	1,461,425	1,461,425
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,054,506	1,054,506
Vivo Capital LLC	[2025-06-30]	SOLE	1,054,506	1,054,506
MPM BioImpact LLC	[2025-06-30]	SOLE	1,054,504	1,054,504
Octagon Capital Advisors LP	[2025-06-30]	SOLE	1,018,021	1,018,021
Yiheng Capital Management LP	[2025-06-30]	SOLE	656,309	656,309
Great Point Partners LLC	[2025-06-30]	SOLE	0	374,679
Millennium Management LLC	[2025-06-30]	SOLE	268,014	268,014
UBS Group AG	[2025-06-30]	DFND	164,200	164,200
NAN FUNG TRINITY (HK) Ltd	[2025-06-30]	SOLE	37,095	37,095
MYDA Advisors LLC	[2025-06-30]	SOLE	30,220	30,220
Morgan Stanley	[2025-06-30]	DFND	17,108	17,474
Point72 Asset Management LP	[2025-06-30]	DFND	0	17,000
Optiver Holding B.V.	[2025-06-30]	DFND	0	8,347
Barclays PLC	[2025-06-30]	SOLE	6,611	6,611
RhumbLine Advisers	[2025-06-30]	SOLE	3,692	3,692
Truvestments Capital LLC	[2025-06-30]	SOLE	1,822	1,822
Steward Partners Investment Advisory LLC	[2025-06-30]	SOLE	0	1,518
Raymond James Financial Inc	[2025-06-30]	DFND	0	916
Eversource Wealth Advisors LLC	[2025-06-30]	SOLE	524	524
Federation des caisses Desjardins du Quebec	[2025-06-30]	DFND	425	425
Gamma Investing LLC	[2025-06-30]	DFND	346	346
Mark Sheptoff Financial Planning LLC	[2025-06-30]	SOLE	300	300
Northwestern Mutual Wealth Management Co	[2025-06-30]	DFND	0	111
Curio Wealth LLC	[2025-06-30]	SOLE	0	27
JPMorgan Chase & Co	[2025-06-30]	DFND	20	20
Trust Co of Toledo NA /OH/	[2025-06-30]	SOLE	10	10
Principal Securities Inc	[2025-06-30]	SOLE	0	8
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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