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Type	Result	AUM ($BB)

Edgewise Therapeutics Inc
Ticker	EWTX
CIK #	0001710072
CUSIP	28036F105
Sector	Life Sciences
Industry	Pharmaceutical Preparations
Phone	3037358373
Address	3415 Colorado Ave Boulder, CO 80303
Source	[EDGAR]

Market Cap, 13F ($)

Shares Owned of Total
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2023-03-31]	DFND	14,301,551.0	14,567,176.0
FMR LLC	[2023-03-31]	DFND	7,940,470.0	7,940,542.0
Novo Holdings A/S	[2023-03-31]	SOLE	6,071,703.0	6,071,703.0
Viking Global Investors LP	[2023-03-31]	SOLE	4,909,146.0	4,909,146.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	3,933,137.0	3,933,137.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	3,493,194.0	3,493,194.0
Deep Track Capital LP	[2023-03-31]	SOLE	3,068,259.0	3,068,259.0
Cormorant Asset Management LP	[2023-03-31]	DFND	2,946,887.0	2,946,887.0
BlackRock Inc.	[2023-03-31]	SOLE	2,818,728.0	2,871,007.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,775,738.0	2,775,738.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,969,874.0
New Leaf Venture Partners LLC	[2023-03-31]	DFND	1,553,661.0	1,553,661.0
Geode Capital Management LLC	[2023-03-31]	DFND	775,487.0	775,487.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	769,799.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	754,119.0	754,139.0
Opaleye Management Inc	[2023-03-31]	SOLE	750,000.0	750,000.0
Granahan Investment Management LLC	[2023-03-31]	SOLE	588,267.0	733,664.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	733,239.0	733,239.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	682,461.0	682,461.0
State Street Corp	[2023-03-31]	DFND	620,023.0	658,623.0
American Century Companies Inc	[2023-03-31]	DFND	476,633.0	509,062.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	500,000.0	500,000.0
Woodline Partners LP	[2023-03-31]	SOLE	360,093.0	360,093.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	340,906.0
Northern Trust Corp	[2023-03-31]	DFND	2,506.0	306,084.0
Candriam SCA	[2023-03-31]	SOLE	298,000.0	298,000.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	294,311.0	294,311.0
Tekla Capital Management LLC	[2023-03-31]	SOLE	1,300,817.0	195,025.0
ExodusPoint Capital Management LP	[2023-03-31]	SOLE	141,851.0	141,851.0
UBS OConnor LLC	[2023-03-31]	DFND	132,968.0	132,968.0
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