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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	8,949,863.0	8,949,863.0
Atlas Venture Life Science Advisors LLC	[2023-03-31]	SOLE	8,279,484.0	8,279,484.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	1,385,216.0	7,597,120.0
Bellevue Group AG	[2023-03-31]	DFND	3,620,280.0	3,620,280.0
BlackRock Inc.	[2023-03-31]	SOLE	3,376,259.0	3,446,364.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	1,085,048.0	3,380,956.0
Artal Group S.A.	[2023-03-31]	DFND	2,814,191.0	2,814,191.0
PFM Health Sciences LP	[2023-03-31]	DFND	0.0	2,648,297.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,202,549.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	1,956,579.0	1,956,579.0
Yiheng Capital Management LP	[2023-03-31]	SOLE	1,601,766.0	1,601,766.0
Great Point Partners LLC	[2023-03-31]	DFND	0.0	1,022,537.0
Geode Capital Management LLC	[2023-03-31]	DFND	933,757.0	933,757.0
State Street Corp	[2023-03-31]	DFND	849,546.0	896,746.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	689,539.0	689,539.0
Bank of America Corp /DE/	[2023-03-31]	DFND	8,471.0	542,800.0
Morgan Stanley	[2023-03-31]	DFND	450,102.0	513,794.0
Harvard Management Co Inc	[2023-03-31]	SOLE	510,354.0	510,354.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	449,693.0	486,271.0
JPMorgan Chase & Co	[2023-03-31]	DFND	405,404.0	463,854.0
UBS Group AG	[2023-03-31]	SOLE	387,283.0	387,283.0
Northern Trust Corp	[2023-03-31]	DFND	6,181.0	385,091.0
Vontobel Holding Ltd.	[2023-03-31]	DFND	385,070.0	385,070.0
Sectoral Asset Management Inc	[2023-03-31]	SOLE	385,070.0	385,070.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	333,545.0	333,545.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	287,000.0	287,000.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	280,622.0	280,622.0
TD Asset Management Inc	[2023-03-31]	SOLE	231,461.0	231,461.0
Atika Capital Management LLC	[2023-03-31]	DFND	186,259.0	186,259.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	128,864.0	161,363.0
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