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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	6,681,307	6,681,307
MPM Asset Management LLC	[2025-06-30]	SOLE	4,309,860	4,309,860
MPM BioImpact LLC	[2025-06-30]	SOLE	2,408,810	2,408,810
Bank of America Corp /DE/	[2025-06-30]	DFND	0	2,129,024
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,287,908
Millennium Management LLC	[2025-06-30]	SOLE	696,695	696,695
Sphera Funds Management Ltd	[2025-06-30]	DFND	626,810	626,810
DC Funds, LP	[2025-06-30]	SOLE	589,102	589,102
PFM Health Sciences LP	[2025-06-30]	DFND	0	401,110
Jane Street Group LLC	[2025-06-30]	DFND	374,939	374,939
BlackRock, Inc.	[2025-06-30]	SOLE	356,667	361,983
Geode Capital Management LLC	[2025-06-30]	DFND	327,955	327,955
Renaissance Technologies LLC	[2025-06-30]	SOLE	316,300	316,300
Alyeska Investment Group LP	[2025-06-30]	SOLE	235,705	235,705
Goldman Sachs Group Inc	[2025-06-30]	DFND	227,442	227,442
State Street Corp	[2025-06-30]	DFND	119,168	119,168
Marshall Wace LLP	[2025-06-30]	OTR	0	103,785
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	102,000	102,000
AQR Capital Management LLC	[2025-06-30]	DFND	90,535	90,535
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	84,421	84,421
Susquehanna International Group LLP	[2025-06-30]	OTR	79,602	79,602
Northern Trust Corp	[2025-06-30]	DFND	65,836	65,836
Acadian Asset Management LLC	[2025-06-30]	DFND	61,277	61,277
Two Sigma Advisers LP	[2025-06-30]	SOLE	48,700	56,600
Edgewood Management LLC	[2025-06-30]	SOLE	50,000	50,000
Two Sigma Investments LP	[2025-06-30]	SOLE	45,422	45,422
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	44,261	44,261
HRT Financial LP	[2025-06-30]	DFND	42,480	42,480
Vontobel Holding Ltd.	[2025-06-30]	DFND	40,000	40,000
Regal Investment Advisors LLC	[2025-06-30]	SOLE	9,345	27,204
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