ISIS Pharmaceuticals Inc
- Stock Issuer and Owners
| ISIS Pharmaceuticals Inc |
| Ticker | IONS |
| CIK # | 0000874015 |
| CUSIP | 462222100 |
| Sector | Life Sciences - Pharmaceutical Preparations |
| Address | 1896 Rutherford Road, Carlsbad, CA 92008 |
| Source |
[EDGAR]
|
| Form 13F Holdings |
| Firm |
Period |
DFND |
Voting |
Shares |
| FMR LLC |
[2025-06-30]
|
DFND |
23,642,636 |
23,642,990 |
| Vanguard Group Inc |
[2025-06-30]
|
SOLE |
0 |
16,438,969 |
| Capital World Investors |
[2025-06-30]
|
DFND |
12,540,188 |
12,540,188 |
| BlackRock, Inc. |
[2025-06-30]
|
SOLE |
10,183,695 |
10,896,544 |
| Bellevue Group AG |
[2025-06-30]
|
DFND |
7,853,198 |
7,853,198 |
| Wellington Management Group LLP |
[2025-06-30]
|
DFND |
0 |
6,345,776 |
| Deep Track Capital LP |
[2025-06-30]
|
SOLE |
4,891,544 |
4,891,544 |
| State Street Corp |
[2025-06-30]
|
DFND |
4,086,741 |
4,530,398 |
| Adage Capital Partners GP LLC |
[2025-06-30]
|
SOLE |
3,800,000 |
3,800,000 |
| Tweedy, Browne Co LLC |
[2025-06-30]
|
SOLE |
2,891,948 |
2,891,948 |
| Geode Capital Management LLC |
[2025-06-30]
|
DFND |
2,891,095 |
2,891,095 |
| Two Sigma Advisers LP |
[2025-06-30]
|
SOLE |
2,562,311 |
2,667,611 |
| Millennium Management LLC |
[2025-06-30]
|
SOLE |
2,649,527 |
2,649,527 |
| BVF Inc/IL |
[2025-06-30]
|
DFND |
0 |
1,913,385 |
| Two Sigma Investments LP |
[2025-06-30]
|
SOLE |
1,788,367 |
1,788,367 |
| Citadel Advisors LLC |
[2025-06-30]
|
DFND |
1,642,281 |
1,642,281 |
| UBS Group AG |
[2025-06-30]
|
DFND |
1,511,548 |
1,529,323 |
| Charles Schwab Investment Management Inc |
[2025-06-30]
|
SOLE |
1,487,818 |
1,487,818 |
| Macquarie Group Ltd |
[2025-06-30]
|
SOLE |
1,434,073 |
1,434,073 |
| Morgan Stanley |
[2025-06-30]
|
DFND |
1,082,395 |
1,362,209 |
| TD Asset Management Inc |
[2025-06-30]
|
SOLE |
1,104,690 |
1,104,690 |
| Balyasny Asset Management LP |
[2025-06-30]
|
SOLE |
1,028,648 |
1,028,648 |
| Polar Capital Holdings Plc |
[2025-06-30]
|
DFND |
1,000,000 |
1,000,000 |
| Bank of America Corp /DE/ |
[2025-06-30]
|
DFND |
44,940 |
995,890 |
| ARK Investment Management LLC |
[2025-06-30]
|
SOLE |
900,318 |
900,318 |
| Voloridge Investment Management LLC |
[2025-06-30]
|
SOLE |
854,634 |
854,634 |
| Northern Trust Corp |
[2025-06-30]
|
DFND |
811,972 |
812,807 |
| Goldman Sachs Group Inc |
[2025-06-30]
|
DFND |
745,123 |
759,578 |
| Hudson Bay Capital Management LP |
[2025-06-30]
|
SOLE |
750,000 |
750,000 |
| Woodline Partners LP |
[2025-06-30]
|
SOLE |
732,813 |
732,813 |
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