ISIS Pharmaceuticals Inc

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ISIS Pharmaceuticals Inc
TickerIONS
CIK #0000874015
CUSIP462222100
SectorLife Sciences - Pharmaceutical Preparations
Address1896 Rutherford Road, Carlsbad, CA 92008
Source [EDGAR]
Reg D Offering (Form D) Filed Raised Terms
ISIS Pharmaceuticals Inc 2012-08-27 201.2 M Exemption: 506 · Duration: One year or less · Revenue: Decline to Disclose
CIK Filing 2011 - 2026
[0000874015] 10-K
[0000874015] 10-Q
[0000874015] 3
[0000874015] 4
[0000874015] 5
[0000874015] 8-K
[0000874015] D
[0000874015] SC 13D
[0000874015] SC 13G
Form 13D/13G Filer Form 13D/13G Subject Filed % Owned
Vanguard Capital Management LLC Ionis Pharmaceuticals Inc [2026-04-30] 0.0
Capital World Investors Ionis Pharmaceuticals Inc [2025-02-13] 0.0
Wellington Management Group LLP Ionis Pharmaceuticals Inc [2024-11-08] 5.76
T Rowe Price Investment Management Inc Ionis Pharmaceuticals Inc [2024-02-14] 9.2
T Rowe Price Investment Management Inc Ionis Pharmaceuticals Inc [2023-02-14] 8.2
Ark Investment Management LLC Ionis Pharmaceuticals Inc [2022-02-09] 5.02
BlackRock Inc Ionis Pharmaceuticals Inc [2022-02-01] 6.0
Price T Rowe Associates Inc /MD/ Ionis Pharmaceuticals Inc [2021-02-16] 9.3
Biogen Inc Ionis Pharmaceuticals Inc [2018-06-07] 8.39
Wellington Management Group LLP Ionis Pharmaceuticals Inc [2018-02-08] 8.76
Ionis Pharmaceuticals Inc Akcea Therapeutics Inc [2017-07-27] 11.0
BlackRock Inc Ionis Pharmaceuticals Inc [2017-01-30] 5.3
Baillie Gifford & Co Ionis Pharmaceuticals Inc [2016-02-05] 6.73
Vanguard Group Inc ISIS Pharmaceuticals Inc [2013-02-13] 5.5
Artisan Partners Holdings LP ISIS Pharmaceuticals Inc [2013-02-06] 5.8
ISIS Pharmaceuticals Inc Regulus Therapeutics Inc [2012-10-19] 11.0
Clearbridge Advisors LLC ISIS Pharmaceuticals Inc [2012-02-14] 5.69
Form 3/4/5 Filer 2011 - 2026
Diaz Allene M
Ionis Pharmaceuticals Inc
Berthelsen Spencer R
Yang Michael J
Loscalzo Joseph
Herman Joan E
Klein Joseph III
Hayden Michael R
Baroldi Joseph
Schneider Eugene
O'Neil Patrick R
Swayze Eric
Monia Brett P
Kordasiewicz Holly B
Hantson Ludwig
Reikes Peter N
Jenne Kyle
Parshall B Lynne
Birchler Brian
Devers Shannon L
Hougen Elizabeth L
Bennett C Frank
Wender Joseph H
Geary Richard S
Cadoret-Manier Onaiza
Muto Frederick T
Crooke Stanley T
Akcea Therapeutics Inc
Castleman Breaux
McDevitt Damien
Boyce Sarah
Regulus Therapeutics Inc
Reed John C
Insider Transaction (Form 3/4/5) Date Action Shares Price Value ($)
Schneider Eugene
Common Stock
2026-03-19 Sell 5,812 $70.97 412,478
Hougen Elizabeth L
Common Stock
2026-03-17 Sell 10,172 $73.21 744,692
Hougen Elizabeth L
Common Stock
2026-03-16 Option exercise 61,041 $56.78 3,465,908
Hougen Elizabeth L
Common Stock
2026-03-16 Option exercise 60,299 $60.89 3,671,606
Hougen Elizabeth L
Non-Qualified Stock Option (right to buy) · derivative
2026-03-16 Option exercise 60,299 $0.00
Hougen Elizabeth L
Common Stock
2026-03-16 Option exercise 20,541 $37.58 771,931
Hougen Elizabeth L
Common Stock
2026-03-16 Sell 9,440 $72.77 686,949
Hougen Elizabeth L
Non-Qualified Stock Option (right to buy) · derivative
2026-03-16 Option exercise 20,541 $0.00
Hougen Elizabeth L
Common Stock
2026-03-16 Option exercise 33,118 $32.60 1,079,647
Hougen Elizabeth L
Non-Qualified Stock Option (right to buy) · derivative
2026-03-16 Option exercise 61,041 $0.00
Hougen Elizabeth L
Non-Qualified Stock Option (right to buy) · derivative
2026-03-16 Option exercise 33,118 $0.00
Hougen Elizabeth L
Common Stock
2026-03-16 Sell 205,608 $72.38 14,881,907
Jenne Kyle
Common Stock
2026-03-10 Option exercise 4,675 $34.69 162,176
Jenne Kyle
Common Stock
2026-03-10 Sell 21,191 $75.50 1,599,920
Jenne Kyle
Common Stock
2026-03-10 Sell 16,086 $76.30 1,227,362
Jenne Kyle
Non-Qualified Stock Option (right to buy) · derivative
2026-03-10 Option exercise 4,675 $0.00
Monia Brett P
Non-Qualified Stock Option (right to buy) · derivative
2026-03-10 Option exercise 34,103 $0.00
Monia Brett P
Common Stock
2026-03-10 Sell 17,591 $76.34 1,342,897
Jenne Kyle
Common Stock
2026-03-10 Option exercise 32,602 $46.10 1,502,952
Jenne Kyle
Non-Qualified Stock Option (right to buy) · derivative
2026-03-10 Option exercise 32,602 $0.00
showing 20 of 200 most recent transactions
13F Ownership Over TimeHoldersShares Held
2026-03-31 497 164,810,872
2025-12-31 499 158,387,337
2025-09-30 446 154,076,921
2025-06-30 369 150,834,338
2025-03-31 351 147,207,981
2024-12-31 362 142,662,455
2024-09-30 358 140,068,716
2024-06-30 360 129,434,535
2024-03-31 363 128,650,976
2023-12-31 368 127,836,407
2023-09-30 316 123,404,611
2023-06-30 310 119,425,744
Form 13F Holdings
Firm Period DFND Voting Shares
Davenport & Company LLC [2026-06-30] SOLE 249,883 283,960
Swedbank AB [2026-06-30] DFND 95,666 95,666
Y-Intercept Hong Kong Ltd [2026-06-30] SOLE 67,374 67,374
Assenagon Asset Management SA [2026-06-30] SOLE 40,927 40,927
Westmount Partners LLC [2026-06-30] SOLE 12,961 12,961
Plancorp LLC [2026-06-30] SOLE 0 11,128
PSP Research LLC [2026-06-30] SOLE 0 6,800
Wedmont Private Capital [2026-06-30] SOLE 0 6,723
Significant Wealth Partners LLC [2026-06-30] SOLE 0 6,613
Cypress Capital LLC [2026-06-30] SOLE 0 6,000
TEMA ETFS LLC [2026-06-30] SOLE 5,525 5,525
Wealth Enhancement Advisory Services LLC [2026-06-30] SOLE 0 5,394
Moisand Fitzgerald Tamayo LLC [2026-06-30] SOLE 5,000 5,000
Gateway Investment Advisers LLC [2026-06-30] SOLE 4,630 4,630
Prospera Financial Services Inc [2026-06-30] SOLE 0 4,194
Crossmark Global Holdings Inc [2026-06-30] SOLE 3,615 3,615
Sequoia Financial Advisors LLC [2026-06-30] SOLE 0 3,567
Everhart Financial Group Inc [2026-06-30] SOLE 0 3,503
Victrix Investment Advisors [2026-06-30] SOLE 0 3,400
Mitchell & PAHL Private Wealth LLC [2026-06-30] SOLE 3,261 3,261
QRG Capital Management Inc [2026-06-30] SOLE 3,079 3,079
Venturi Wealth Management LLC [2026-06-30] OTR 0 3,061
B Riley Wealth Advisors Inc [2026-06-30] SOLE 2,897 2,897
Gamma Investing LLC [2026-06-30] DFND 2,168 2,168
Versant Capital Management Inc [2026-06-30] SOLE 1,460 1,460
Harbor Investment Advisory LLC [2026-06-30] SOLE 1,407 1,407
Farther Finance Advisors LLC [2026-06-30] SOLE 0 1,111
IFP Advisors LLC [2026-06-30] SOLE 952 952
Handelsbanken Fonder AB [2026-06-30] SOLE 0 383
Corecap Advisors LLC [2026-06-30] SOLE 0 370
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